Product Information
ISOSORBIDE DINITRATE 40 MG TAB is a generic product labeled by Advagen Pharma Ltd., priced at $3.2138 per EA under NDC 72888008501. Its NADAC has been published 105 times since Aug 21, 2024.
FDA first approved this application on Jul 8, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/1
Manufacturer
Advagen Pharma Ltd.NDC
72888008501
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ISOSORBIDE DINITRATEApproval Type
Generic (ANDA)
FDA Application
ANDA215723FDA Approved
7/8/2022
TE Code
AB
On Market Since
7/8/2022
Pharmacological Classes
Price Statistics
The NADAC for ISOSORBIDE DINITRATE 40 MG TAB has been published 105 times since Aug 21, 2024, and over the history we have for it it has risen 45.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.2138 per EA |
|---|---|
| All-time high | $3.2138 (Aug 19, 2026) |
| All-time low | $1.8875 (Oct 23, 2024) |
| 52-week high | $3.2138 |
| 52-week low | $2.5308 |
| Median price | $2.5349 |
| Average price | $2.5170 |
| Largest weekly change | +13.4% (Mar 19, 2025) |
| Weeks tracked | 105 |
| Tracking since | Aug 21, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 20% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ISOSORBIDE DINITRATE 40 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for ISOSORBIDE DINITRATE 40 MG TAB, manufactured by Advagen Pharma Ltd., is $3.2138 per EA (NDC 72888008501), effective Aug 19, 2026.
How has the price of ISOSORBIDE DINITRATE 40 MG TAB changed over time?
Over the history we have for it, the NADAC for ISOSORBIDE DINITRATE 40 MG TAB has risen 45.1%. It has been tracked across 105 weekly CMS publications since Aug 21, 2024.
What are the highest and lowest recorded NADAC prices for ISOSORBIDE DINITRATE 40 MG TAB?
Since Aug 21, 2024, the NADAC for ISOSORBIDE DINITRATE 40 MG TAB has ranged from a low of $1.8875 (Oct 23, 2024) to a high of $3.2138 (Aug 19, 2026), with a median of $2.5349 per EA.
Are there cheaper alternatives to ISOSORBIDE DINITRATE 40 MG TAB?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ISOSORBIDE DINITRATE 40 MG TAB, is $2.5851 per EA — about 20% below ISOSORBIDE DINITRATE 40 MG TAB.
Who manufactures ISOSORBIDE DINITRATE 40 MG TAB?
ISOSORBIDE DINITRATE 40 MG TAB (NDC 72888008501) is labeled by Advagen Pharma Ltd., and CMS classifies it as a generic product.