Isosorbide Dinitrate
54 NDCs across 13 manufacturers|53 Generic,1 Brand
Isosorbide Dinitrate is used to treat angina pectoris, coronary disease, cyanosis, diffuse esophageal spasm, gastroesophageal reflux and heart failure, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on Jul 29, 1988, and the first generic was approved Sep 18, 1986. FDA's Orange Book lists 23 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $28 million on Isosorbide Dinitrate across 539,000 claims for 133,000 beneficiaries.
Isosorbide Dinitrate is available as 54 NDCs from 13 manufacturers (53 generic, 1 brand), with NADAC prices from $0.16 to $17.35 per EA — the most expensive product costs about 109× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
54
53G / 1B
Manufacturers
13
competing in market
Price Spread
$0.16 – $17.35
per EA
7d Activity
avg -4.4% WoW · of 54 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Manufacturer Breakdown
13 manufacturers producing ISOSORBIDE DINITRATE(2 pricing outliers)
Frequently Asked Questions
What is Isosorbide Dinitrate used to treat?
Isosorbide Dinitrate is used to treat angina pectoris, coronary disease, cyanosis, diffuse esophageal spasm, gastroesophageal reflux and heart failure, per the National Library of Medicine's MED-RT classification.
When did Isosorbide Dinitrate become available as a generic?
FDA approved the first generic Isosorbide Dinitrate (ANDA) on Sep 18, 1986. The Orange Book currently lists 23 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Isosorbide Dinitrate?
In 2024, Medicare Part D spent $28 million on Isosorbide Dinitrate across 539,000 claims for 133,000 beneficiaries.
How many Isosorbide Dinitrate products are on the market?
The Isosorbide Dinitrate drug market contains 54 NDCs from 13 manufacturers — 53 generic and 1 brand product.
What is the price range for Isosorbide Dinitrate?
NADAC reference prices for Isosorbide Dinitrate range from $0.1596 to $17.3458 per EA — the most expensive product costs about 109× the cheapest.
Is generic Isosorbide Dinitrate cheaper than brand?
The average generic NADAC for Isosorbide Dinitrate is $0.4176 per EA, versus $17.3458 for brand-labeled products — brand versions average about 42× the generic price.
Which manufacturers make Isosorbide Dinitrate?
13 manufacturers list Isosorbide Dinitrate in NADAC. Ranked by number of NDCs, the largest are Advagen Pharma Ltd. (9), Endo USA Inc. (9), Hikma Pharmaceuticals USA Inc. (6), Sandoz Inc. (6), Zydus Pharmaceuticals (USA) Inc. (5).
How has the price of Isosorbide Dinitrate changed recently?
Over the past 7 days, 3 Isosorbide Dinitrate NDCs rose and 47 fell, with a market-wide average change of -4.4%.