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Product Information

DIPHENHYDRAMINE 12.5 MG/5 ML is a generic product labeled by Kesin Pharma Corporation, priced at $0.0175 per ML under NDC 81033002916. Its NADAC has been published 43 times since Oct 29, 2025.

DIPHENHYDRAMINE 12.5 MG/5 ML

Diphenhydramine HCl Oral Solution
$0.0175per ML
OTC

Strength

12.5 mg/5mL

NDC

81033002916

Classification

Generic

Dosage Form

SOLUTION

Route

ORAL

Effective Date

8/19/2026

Active Ingredients

DIPHENHYDRAMINE HCL

Approval Type

OTC MONOGRAPH DRUG

FDA Application

M012

On Market Since

3/4/2025

Pharmacological Classes

Histamine H1 Receptor Antagonists
Histamine-1 Receptor Antagonist

Price Statistics

The NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has been published 43 times since Oct 29, 2025, and over the history we have for it it has risen 42.0%. The table below summarizes its recorded NADAC range and movement.

Current price$0.0175 per ML
All-time high$0.0178 (Feb 11, 2026)
All-time low$0.0123 (Oct 29, 2025)
52-week high$0.0178
52-week low$0.0123
Median price$0.0170
Average price$0.0164
Largest weekly change+17.4% (Nov 19, 2025)
Weeks tracked43
Tracking sinceOct 29, 2025

Price History

1W

+3.2%

1M

+3.2%

3M

+2.2%

6M

+2.2%

1Y

N/A

3Y

N/A

5Y

N/A

All

+42.0%

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Diphenhydramine HCl Oral Solution market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

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Frequently asked questions

What is the NADAC price of DIPHENHYDRAMINE 12.5 MG/5 ML?

The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 12.5 MG/5 ML, manufactured by Kesin Pharma Corporation, is $0.0175 per ML (NDC 81033002916), effective Aug 19, 2026.

How has the price of DIPHENHYDRAMINE 12.5 MG/5 ML changed over time?

Over the history we have for it, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has risen 42.0%. It has been tracked across 43 weekly CMS publications since Oct 29, 2025.

What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 12.5 MG/5 ML?

Since Oct 29, 2025, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has ranged from a low of $0.0123 (Oct 29, 2025) to a high of $0.0178 (Feb 11, 2026), with a median of $0.0170 per ML.

Are there cheaper alternatives to DIPHENHYDRAMINE 12.5 MG/5 ML?

No other NADAC-published product currently shares the active ingredient and strength of DIPHENHYDRAMINE 12.5 MG/5 ML in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures DIPHENHYDRAMINE 12.5 MG/5 ML?

DIPHENHYDRAMINE 12.5 MG/5 ML (NDC 81033002916) is labeled by Kesin Pharma Corporation, and CMS classifies it as a generic product.