Epinephrine
18 NDCs across 8 manufacturers|10 Generic,8 Brand
Epinephrine is used to treat airway obstruction, anaphylaxis, bradycardia, bronchial spasm, open-angle glaucoma and heart arrest, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved May 23, 1984. FDA's Orange Book lists 4 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $120 million on Epinephrine across 583,000 claims for 463,000 beneficiaries.
Epinephrine is available as 18 NDCs from 8 manufacturers (10 generic, 8 brand), with NADAC prices from $112.00 to $360.14 per EA — the most expensive product costs about 3.2× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Active FDA drug shortage
22 Epinephrine presentations are currently listed in FDA's drug shortage database (first posted Feb 22, 2012). Shortages can move NADAC prices in the following weeks.
Total NDCs
18
10G / 8B
Manufacturers
8
competing in market
Price Spread
$112.00 – $360.14
per EA, 15 of 18 NDCs
7d Activity
avg +0.0% WoW · of 18 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Viatris Specialty LLC manufacturer profile
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Lead class
Catecholamine class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
8 manufacturers producing EPINEPHRINE
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
NEFFY 1 MG/0.1 ML NASAL SPRAY | $360.1376 per EA | -0.07% |
NEFFY 2 MG/0.1 ML NASAL SPRAY | $359.4923 per EA | -0.02% |
AUVI-Q 0.15 MG AUTO-INJECTOR | $309.8510 per EA | — |
AUVI-Q 0.1 MG AUTO-INJECTOR | $309.5523 per EA | — |
AUVI-Q 0.3 MG AUTO-INJECTOR | $309.3757 per EA | — |
EPIPEN JR 2-PAK 0.15 MG INJCTR | $290.6380 per EA | — |
EPIPEN 2-PAK 0.3 MG AUTO-INJCT | $289.9600 per EA | — |
EPINEPHRINE 0.15 MG AUTO-INJCT | $141.8818 per EA | +0.02% |
EPINEPHRINE 0.3 MG AUTO-INJECT | $141.2757 per EA | +0.10% |
EPINEPHRINE 0.3 MG AUTO-INJECT | $133.5966 per EA | +0.58% |
EPINEPHRINE 0.15 MG AUTO-INJCT | $129.0533 per EA | +1.46% |
EPINEPHRINE 0.15 MG AUTO-INJCT | $117.9660 per EA | -0.53% |
EPINEPHRINE 0.15 MG AUTO-INJCT | $117.9660 per EA | -0.53% |
EPINEPHRINE 0.3 MG AUTO-INJECT | $111.9976 per EA | -0.88% |
EPINEPHRINE 0.3 MG AUTO-INJECT | $111.9976 per EA | -0.88% |
ADRENALIN 1 MG/ML VIAL | $7.7955 per ML | — |
EPINEPHRINE 1 MG/10 ML LUERJET | $1.2380 per ML | +0.96% |
EPINEPHRINE 1 MG/10 ML ABBOJCT | $1.1940 per ML | — |
Frequently Asked Questions
What is Epinephrine used to treat?
Epinephrine is used to treat airway obstruction, anaphylaxis, bradycardia, bronchial spasm, open-angle glaucoma and heart arrest, per the National Library of Medicine's MED-RT classification.
When did Epinephrine become available as a generic?
FDA approved the first generic Epinephrine (ANDA) on May 23, 1984. The Orange Book currently lists 4 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Epinephrine?
In 2024, Medicare Part D spent $120 million on Epinephrine across 583,000 claims for 463,000 beneficiaries.
Is Epinephrine in shortage?
Yes — FDA's drug shortage database currently lists 22 Epinephrine presentations with status "Current", first posted Feb 22, 2012.
How many Epinephrine products are on the market?
The Epinephrine drug market contains 18 NDCs from 8 manufacturers — 10 generic and 8 brand products.
What is the price range for Epinephrine?
NADAC reference prices for Epinephrine range from $111.9976 to $360.1376 per EA — the most expensive product costs about 3.2× the cheapest. 3 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Is generic Epinephrine cheaper than brand?
The average generic NADAC for Epinephrine is $125.7168 per EA, versus $318.4296 for brand-labeled products — brand versions average about 2.5× the generic price.
Which manufacturers make Epinephrine?
8 manufacturers list Epinephrine in NADAC. Ranked by number of NDCs, the largest are Viatris Specialty LLC (4), Amneal Pharmaceuticals of New York LLC (4), kaleo, Inc (3), ARS Pharmaceuticals Operations, Inc. (2), Teva Pharmaceuticals USA Inc. (2).
How has the price of Epinephrine changed recently?
Over the past 7 days, 15 Epinephrine NDCs rose and 18 fell, with a market-wide average change of +0.0%.