Product Information
EPIPEN 2-PAK 0.3 MG AUTO-INJCT is a brand product labeled by Viatris Specialty LLC, priced at $289.9600 per EA under NDC 49502050002. Its NADAC has been published 622 times since Nov 28, 2013.
FDA first approved this application on Dec 22, 1987. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.3 mg/.3mL
Manufacturer
Viatris Specialty LLCNDC
49502050002
Classification
Brand
Dosage Form
INJECTION
Route
INTRAMUSCULAR
Effective Date
11/20/2024
Active Ingredients
EPINEPHRINEApproval Type
New Drug (NDA)
FDA Application
NDA019430FDA Approved
12/22/1987
TE Code
AB
On Market Since
12/22/1987
Pharmacological Classes
Price Statistics
The NADAC for EPIPEN 2-PAK 0.3 MG AUTO-INJCT has been published 622 times since Nov 28, 2013, and over the history we have for it it has risen 99.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $289.9600 per EA |
|---|---|
| All-time high | $294.6936 (Jul 13, 2016) |
| All-time low | $145.7261 (Nov 28, 2013) |
| 52-week high | $289.9600 |
| 52-week low | $289.9600 |
| Median price | $292.1743 |
| Average price | $273.3161 |
| Largest weekly change | +14.9% (May 13, 2015) |
| Weeks tracked | 622 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
0.0%
3Y
-1.0%
5Y
-0.0%
All
+99.0%
Last surveyed Nov 12, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 61% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Viatris Specialty LLC manufacturer profile
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Drug market
epinephrine market comparison
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Therapeutic class
Catecholamine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of EPIPEN 2-PAK 0.3 MG AUTO-INJCT?
The current National Average Drug Acquisition Cost (NADAC) for EPIPEN 2-PAK 0.3 MG AUTO-INJCT, manufactured by Viatris Specialty LLC, is $289.9600 per EA (NDC 49502050002), effective Nov 12, 2025.
How has the price of EPIPEN 2-PAK 0.3 MG AUTO-INJCT changed over time?
Over the history we have for it, the NADAC for EPIPEN 2-PAK 0.3 MG AUTO-INJCT has risen 99.0%. It has been tracked across 622 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for EPIPEN 2-PAK 0.3 MG AUTO-INJCT?
Since Nov 28, 2013, the NADAC for EPIPEN 2-PAK 0.3 MG AUTO-INJCT has ranged from a low of $145.7261 (Nov 28, 2013) to a high of $294.6936 (Jul 13, 2016), with a median of $292.1743 per EA.
Are there cheaper alternatives to EPIPEN 2-PAK 0.3 MG AUTO-INJCT?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, EPINEPHRINE 0.3 MG AUTO-INJECT, is $111.9976 per EA — about 61% below EPIPEN 2-PAK 0.3 MG AUTO-INJCT.
Who manufactures EPIPEN 2-PAK 0.3 MG AUTO-INJCT?
EPIPEN 2-PAK 0.3 MG AUTO-INJCT (NDC 49502050002) is labeled by Viatris Specialty LLC, and CMS classifies it as a brand product.