Product Information
CHLORTHALIDONE 25 MG TABLET is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $0.0743 per EA under NDC 00378022210. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378022210
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
CHLORTHALIDONEApproval Type
Generic (ANDA)
FDA Application
ANDA086831FDA Approved
Before 1982
TE Code
AB
On Market Since
2/26/1981
Pharmacological Classes
Price Statistics
The NADAC for CHLORTHALIDONE 25 MG TABLET has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 82.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0743 per EA |
|---|---|
| All-time high | $0.8801 (May 11, 2016) |
| All-time low | $0.0703 (Jul 17, 2024) |
| 52-week high | $0.0901 |
| 52-week low | $0.0743 |
| Median price | $0.3484 |
| Average price | $0.3986 |
| Largest weekly change | +43.1% (Jun 25, 2014) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
chlorthalidone market comparison
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Therapeutic class
Thiazide-like Diuretic class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CHLORTHALIDONE 25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for CHLORTHALIDONE 25 MG TABLET, manufactured by Mylan Pharmaceuticals Inc., is $0.0743 per EA (NDC 00378022210), effective Sep 30, 2026.
How has the price of CHLORTHALIDONE 25 MG TABLET changed over time?
Over the history we have for it, the NADAC for CHLORTHALIDONE 25 MG TABLET has declined 82.3%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for CHLORTHALIDONE 25 MG TABLET?
Since Nov 28, 2013, the NADAC for CHLORTHALIDONE 25 MG TABLET has ranged from a low of $0.0703 (Jul 17, 2024) to a high of $0.8801 (May 11, 2016), with a median of $0.3484 per EA.
Are there cheaper alternatives to CHLORTHALIDONE 25 MG TABLET?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as CHLORTHALIDONE 25 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures CHLORTHALIDONE 25 MG TABLET?
CHLORTHALIDONE 25 MG TABLET (NDC 00378022210) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.