Chlorthalidone
63 NDCs across 22 manufacturers|60 Generic,3 Brand
Chlorthalidone is used to treat edema, glomerulonephritis, heart failure, hypertension, liver cirrhosis and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 34 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $49 million on Chlorthalidone across 2.9 million claims for 816,000 beneficiaries.
Chlorthalidone is available as 63 NDCs from 22 manufacturers (60 generic, 3 brand), with NADAC prices from $0.07 to $3.54 per EA — the most expensive product costs about 48× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
63
60G / 3B
Manufacturers
22
competing in market
Price Spread
$0.07 – $3.54
per EA
7d Activity
avg -6.2% WoW · of 63 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Dr. Reddy's Laboratories Inc. manufacturer profile
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Lead class
Thiazide-like Diuretic class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
22 manufacturers producing CHLORTHALIDONE(6 pricing outliers)
Frequently Asked Questions
What is Chlorthalidone used to treat?
Chlorthalidone is used to treat edema, glomerulonephritis, heart failure, hypertension, liver cirrhosis and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
When did Chlorthalidone become available as a generic?
FDA approved the first generic Chlorthalidone (ANDA) on Jan 1, 1982. The Orange Book currently lists 34 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Chlorthalidone?
In 2024, Medicare Part D spent $49 million on Chlorthalidone across 2.9 million claims for 816,000 beneficiaries.
How many Chlorthalidone products are on the market?
The Chlorthalidone drug market contains 63 NDCs from 22 manufacturers — 60 generic and 3 brand products.
What is the price range for Chlorthalidone?
NADAC reference prices for Chlorthalidone range from $0.0743 to $3.5423 per EA — the most expensive product costs about 48× the cheapest.
Is generic Chlorthalidone cheaper than brand?
The average generic NADAC for Chlorthalidone is $0.0946 per EA, versus $1.8188 for brand-labeled products — brand versions average about 19× the generic price.
Which manufacturers make Chlorthalidone?
22 manufacturers list Chlorthalidone in NADAC. Ranked by number of NDCs, the largest are Dr. Reddy's Laboratories Inc. (8), Rising Pharma Holdings Inc. (6), Mylan Pharmaceuticals Inc. (4), Chartwell RX LLC (4), Lifestar Pharma LLC (4).
How has the price of Chlorthalidone changed recently?
Over the past 7 days, 25 Chlorthalidone NDCs rose and 32 fell, with a market-wide average change of -6.2%.