Product Information
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $0.4960 per EA under NDC 00378040305. Its NADAC has been published 481 times since Jun 7, 2017.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25; 25 mg/1; mg/1
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378040305
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
HYDROCHLOROTHIAZIDE; SPIRONOLACTONEApproval Type
Generic (ANDA)
FDA Application
ANDA086513FDA Approved
Before 1982
TE Code
AB
On Market Since
8/3/1979
Pharmacological Classes
Price Statistics
The NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has been published 481 times since Jun 7, 2017, and over the history we have for it it has declined 40.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4960 per EA |
|---|---|
| All-time high | $0.9563 (Sep 13, 2017) |
| All-time low | $0.3906 (Nov 20, 2024) |
| 52-week high | $0.5749 |
| 52-week low | $0.4960 |
| Median price | $0.6816 |
| Average price | $0.6839 |
| Largest weekly change | +37.7% (Aug 21, 2024) |
| Weeks tracked | 481 |
| Tracking since | Jun 7, 2017 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
The current National Average Drug Acquisition Cost (NADAC) for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB, manufactured by Mylan Pharmaceuticals Inc., is $0.4960 per EA (NDC 00378040305), effective Aug 19, 2026.
How has the price of SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB changed over time?
Over the history we have for it, the NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has declined 40.9%. It has been tracked across 481 weekly CMS publications since Jun 7, 2017.
What are the highest and lowest recorded NADAC prices for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
Since Jun 7, 2017, the NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has ranged from a low of $0.3906 (Nov 20, 2024) to a high of $0.9563 (Sep 13, 2017), with a median of $0.6816 per EA.
Are there cheaper alternatives to SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB (NDC 00378040305) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.