Product Information
PENCICLOVIR 1% CREAM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $50.0832 per GM under NDC 00378089655. Its NADAC has been published 183 times since Feb 22, 2023.
FDA first approved this application on Sep 24, 1996. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the penciclovir market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
10 mg/g
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378089655
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
PENCICLOVIRApproval Type
Authorized Generic (NDA)
FDA Application
NDA020629FDA Approved
9/24/1996
TE Code
AB
On Market Since
11/16/2022
Pharmacological Classes
Price Statistics
The NADAC for PENCICLOVIR 1% CREAM has been published 183 times since Feb 22, 2023, and over the history we have for it it has declined 53.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $50.0832 per GM |
|---|---|
| All-time high | $108.5362 (Feb 12, 2025) |
| All-time low | $46.3296 (Aug 20, 2025) |
| 52-week high | $65.5085 |
| 52-week low | $46.3296 |
| Median price | $89.6904 |
| Average price | $83.6800 |
| Largest weekly change | -20.8% (Apr 23, 2025) |
| Weeks tracked | 183 |
| Tracking since | Feb 22, 2023 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PENCICLOVIR 1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for PENCICLOVIR 1% CREAM, manufactured by Mylan Pharmaceuticals Inc., is $50.0832 per GM (NDC 00378089655), effective Aug 19, 2026.
How has the price of PENCICLOVIR 1% CREAM changed over time?
Over the history we have for it, the NADAC for PENCICLOVIR 1% CREAM has declined 53.4%. It has been tracked across 183 weekly CMS publications since Feb 22, 2023.
What are the highest and lowest recorded NADAC prices for PENCICLOVIR 1% CREAM?
Since Feb 22, 2023, the NADAC for PENCICLOVIR 1% CREAM has ranged from a low of $46.3296 (Aug 20, 2025) to a high of $108.5362 (Feb 12, 2025), with a median of $89.6904 per GM.
Are there cheaper alternatives to PENCICLOVIR 1% CREAM?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PENCICLOVIR 1% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures PENCICLOVIR 1% CREAM?
PENCICLOVIR 1% CREAM (NDC 00378089655) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.