Product Information
PENCICLOVIR 1% CREAM is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $52.1538 per GM under NDC 45802044075. Its NADAC has been published 94 times since Dec 18, 2024.
FDA first approved this application on Sep 27, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10 mg/g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802044075
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
PENCICLOVIRApproval Type
Generic (ANDA)
FDA Application
ANDA212368FDA Approved
9/27/2024
TE Code
AB
On Market Since
11/7/2024
Pharmacological Classes
Price Statistics
The NADAC for PENCICLOVIR 1% CREAM has been published 94 times since Dec 18, 2024, and over the history we have for it it has declined 49.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $52.1538 per GM |
|---|---|
| All-time high | $108.5362 (Feb 12, 2025) |
| All-time low | $46.3296 (Aug 20, 2025) |
| 52-week high | $65.5085 |
| 52-week low | $48.8840 |
| Median price | $59.8769 |
| Average price | $64.7373 |
| Largest weekly change | -20.8% (Apr 23, 2025) |
| Weeks tracked | 94 |
| Tracking since | Dec 18, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
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Drug market
penciclovir market comparison
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Therapeutic class
Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PENCICLOVIR 1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for PENCICLOVIR 1% CREAM, manufactured by Padagis Israel Pharmaceuticals Ltd, is $52.1538 per GM (NDC 45802044075), effective Sep 30, 2026.
How has the price of PENCICLOVIR 1% CREAM changed over time?
Over the history we have for it, the NADAC for PENCICLOVIR 1% CREAM has declined 49.5%. It has been tracked across 94 weekly CMS publications since Dec 18, 2024.
What are the highest and lowest recorded NADAC prices for PENCICLOVIR 1% CREAM?
Since Dec 18, 2024, the NADAC for PENCICLOVIR 1% CREAM has ranged from a low of $46.3296 (Aug 20, 2025) to a high of $108.5362 (Feb 12, 2025), with a median of $59.8769 per GM.
Are there cheaper alternatives to PENCICLOVIR 1% CREAM?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PENCICLOVIR 1% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures PENCICLOVIR 1% CREAM?
PENCICLOVIR 1% CREAM (NDC 45802044075) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.