Product Information
PROGRAF 5 MG CAPSULE is a brand product labeled by Astellas Pharma US, Inc., priced at $35.6341 per EA under NDC 00469065773. Its NADAC has been published 69 times since Nov 28, 2013.
FDA first approved this application on Apr 8, 1994. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Tacrolimus market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
5 mg/1
Manufacturer
Astellas Pharma US, Inc.NDC
00469065773
Classification
Brand
Dosage Form
CAPSULE, GELATIN COATED
Route
ORAL
Effective Date
1/22/2025
Active Ingredients
TACROLIMUSApproval Type
New Drug (NDA)
FDA Application
NDA050708FDA Approved
4/8/1994
TE Code
AB
On Market Since
4/8/1994
Pharmacological Classes
Price Statistics
The NADAC for PROGRAF 5 MG CAPSULE has been published 69 times since Nov 28, 2013, and over the history we have for it it has risen 82.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $35.6341 per EA |
|---|---|
| All-time high | $35.6341 (Jan 14, 2026) |
| All-time low | $19.5743 (Nov 28, 2013) |
| 52-week high | $35.6341 |
| 52-week low | $35.6341 |
| Median price | $35.6341 |
| Average price | $31.6773 |
| Largest weekly change | +82.0% (Jan 22, 2025) |
| Weeks tracked | 69 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
0.0%
3Y
+82.0%
5Y
+82.0%
All
+82.0%
Last surveyed Jan 14, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 98% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROGRAF 5 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for PROGRAF 5 MG CAPSULE, manufactured by Astellas Pharma US, Inc., is $35.6341 per EA (NDC 00469065773), effective Jan 14, 2026.
How has the price of PROGRAF 5 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for PROGRAF 5 MG CAPSULE has risen 82.0%. It has been tracked across 69 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROGRAF 5 MG CAPSULE?
Since Nov 28, 2013, the NADAC for PROGRAF 5 MG CAPSULE has ranged from a low of $19.5743 (Nov 28, 2013) to a high of $35.6341 (Jan 14, 2026), with a median of $35.6341 per EA.
Are there cheaper alternatives to PROGRAF 5 MG CAPSULE?
Yes. 12 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TACROLIMUS 5 MG CAPSULE (IMMEDIATE RELEASE), is $0.6591 per EA — about 98% below PROGRAF 5 MG CAPSULE.
Who manufactures PROGRAF 5 MG CAPSULE?
PROGRAF 5 MG CAPSULE (NDC 00469065773) is labeled by Astellas Pharma US, Inc., and CMS classifies it as a brand product.