Product Information
AMITRIPTYLINE HCL 25 MG TAB is a generic product labeled by Sandoz Inc., priced at $0.0522 per EA under NDC 00781148710. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Sandoz Inc.NDC
00781148710
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
AMITRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA085968FDA Approved
Before 1982
TE Code
AB
On Market Since
11/21/1977
Pharmacological Classes
Price Statistics
The NADAC for AMITRIPTYLINE HCL 25 MG TAB has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 195.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0522 per EA |
|---|---|
| All-time high | $0.2717 (Sep 10, 2014) |
| All-time low | $0.0170 (Jun 18, 2014) |
| 52-week high | $0.0566 |
| 52-week low | $0.0509 |
| Median price | $0.0940 |
| Average price | $0.1274 |
| Largest weekly change | +673.7% (Jul 23, 2014) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Sandoz Inc. manufacturer profile
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Drug market
Amitriptyline Hydrochloride market comparison
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Therapeutic class
Tricyclic Antidepressant class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of AMITRIPTYLINE HCL 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for AMITRIPTYLINE HCL 25 MG TAB, manufactured by Sandoz Inc., is $0.0522 per EA (NDC 00781148710), effective Sep 30, 2026.
How has the price of AMITRIPTYLINE HCL 25 MG TAB changed over time?
Over the history we have for it, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has risen 195.0%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for AMITRIPTYLINE HCL 25 MG TAB?
Since Nov 28, 2013, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has ranged from a low of $0.0170 (Jun 18, 2014) to a high of $0.2717 (Sep 10, 2014), with a median of $0.0940 per EA.
Are there cheaper alternatives to AMITRIPTYLINE HCL 25 MG TAB?
12 manufacturers publish a NADAC-priced product with the same active ingredient and strength as AMITRIPTYLINE HCL 25 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures AMITRIPTYLINE HCL 25 MG TAB?
AMITRIPTYLINE HCL 25 MG TAB (NDC 00781148710) is labeled by Sandoz Inc., and CMS classifies it as a generic product.