Product Information
AMITRIPTYLINE HCL 25 MG TAB is a generic product labeled by AvPAK, priced at $0.0522 per EA under NDC 50268003815. Its NADAC has been published 156 times since Oct 11, 2023.
FDA first approved this application on May 19, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The Low Outlier badge above means this manufacturer's average price in the Amitriptyline Hydrochloride market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25 mg/1
Manufacturer
AvPAKNDC
50268003815
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
AMITRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA214548FDA Approved
5/19/2021
TE Code
AB
On Market Since
6/6/2023
Pharmacological Classes
Price Statistics
The NADAC for AMITRIPTYLINE HCL 25 MG TAB has been published 156 times since Oct 11, 2023, and over the history we have for it it has declined 16.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0522 per EA |
|---|---|
| All-time high | $0.0703 (Apr 10, 2024) |
| All-time low | $0.0411 (Nov 20, 2024) |
| 52-week high | $0.0566 |
| 52-week low | $0.0509 |
| Median price | $0.0553 |
| Average price | $0.0558 |
| Largest weekly change | -27.3% (Nov 20, 2024) |
| Weeks tracked | 156 |
| Tracking since | Oct 11, 2023 |
Generic Alternatives
The matcher finds 11 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
AvPAK manufacturer profile
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Drug market
Amitriptyline Hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Tricyclic Antidepressant class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of AMITRIPTYLINE HCL 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for AMITRIPTYLINE HCL 25 MG TAB, manufactured by AvPAK, is $0.0522 per EA (NDC 50268003815), effective Sep 30, 2026.
How has the price of AMITRIPTYLINE HCL 25 MG TAB changed over time?
Over the history we have for it, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has declined 16.1%. It has been tracked across 156 weekly CMS publications since Oct 11, 2023.
What are the highest and lowest recorded NADAC prices for AMITRIPTYLINE HCL 25 MG TAB?
Since Oct 11, 2023, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has ranged from a low of $0.0411 (Nov 20, 2024) to a high of $0.0703 (Apr 10, 2024), with a median of $0.0553 per EA.
Are there cheaper alternatives to AMITRIPTYLINE HCL 25 MG TAB?
11 manufacturers publish a NADAC-priced product with the same active ingredient and strength as AMITRIPTYLINE HCL 25 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures AMITRIPTYLINE HCL 25 MG TAB?
AMITRIPTYLINE HCL 25 MG TAB (NDC 50268003815) is labeled by AvPAK, and CMS classifies it as a generic product.