Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $2.4609 per ML under NDC 00832142510. Its NADAC has been published 170 times since May 24, 2023.
FDA first approved this application on Dec 12, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Upsher-Smith Laboratories LLCNDC
00832142510
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA215598FDA Approved
12/12/2022
TE Code
AB
On Market Since
12/15/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 170 times since May 24, 2023, and over the history we have for it it has declined 87.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.4609 per ML |
|---|---|
| All-time high | $19.2842 (Jun 14, 2023) |
| All-time low | $2.3704 (May 20, 2026) |
| 52-week high | $4.6326 |
| 52-week low | $2.3704 |
| Median price | $8.4605 |
| Average price | $8.9476 |
| Largest weekly change | +56.9% (May 22, 2024) |
| Weeks tracked | 170 |
| Tracking since | May 24, 2023 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 25% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Upsher-Smith Laboratories LLC, is $2.4609 per ML (NDC 00832142510), effective Aug 19, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 87.2%. It has been tracked across 170 weekly CMS publications since May 24, 2023.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since May 24, 2023, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.3704 (May 20, 2026) to a high of $19.2842 (Jun 14, 2023), with a median of $8.4605 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.8390 per ML — about 25% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 00832142510) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.