Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $2.1513 per ML under NDC 00832142510. Its NADAC has been published 176 times since May 24, 2023.
FDA first approved this application on Dec 12, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Upsher-Smith Laboratories LLCNDC
00832142510
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA215598FDA Approved
12/12/2022
TE Code
AB
On Market Since
12/15/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 176 times since May 24, 2023, and over the history we have for it it has declined 88.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.1513 per ML |
|---|---|
| All-time high | $19.2842 (Jun 14, 2023) |
| All-time low | $2.1513 (Sep 23, 2026) |
| 52-week high | $3.7359 |
| 52-week low | $2.1513 |
| Median price | $8.2868 |
| Average price | $8.7229 |
| Largest weekly change | +56.9% (May 22, 2024) |
| Weeks tracked | 176 |
| Tracking since | May 24, 2023 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 8% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Upsher-Smith Laboratories LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Brimonidine Tartrate and Timolol Maleate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
alpha-Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Upsher-Smith Laboratories LLC, is $2.1513 per ML (NDC 00832142510), effective Sep 30, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 88.8%. It has been tracked across 176 weekly CMS publications since May 24, 2023.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since May 24, 2023, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.1513 (Sep 23, 2026) to a high of $19.2842 (Jun 14, 2023), with a median of $8.2868 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.9717 per ML — about 8% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 00832142510) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.