Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Sandoz Inc., priced at $2.1513 per ML under NDC 00781718670. Its NADAC has been published 220 times since Jul 20, 2022.
FDA first approved this application on Apr 4, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Sandoz Inc.NDC
00781718670
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA091087FDA Approved
4/4/2022
TE Code
AB
On Market Since
4/13/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 220 times since Jul 20, 2022, and over the history we have for it it has declined 91.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.1513 per ML |
|---|---|
| All-time high | $32.9940 (Sep 14, 2022) |
| All-time low | $2.1513 (Sep 23, 2026) |
| 52-week high | $3.7359 |
| 52-week low | $2.1513 |
| Median price | $9.8370 |
| Average price | $12.2875 |
| Largest weekly change | +56.9% (May 22, 2024) |
| Weeks tracked | 220 |
| Tracking since | Jul 20, 2022 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 8% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Sandoz Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Brimonidine Tartrate and Timolol Maleate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
alpha-Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Sandoz Inc., is $2.1513 per ML (NDC 00781718670), effective Sep 30, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 91.2%. It has been tracked across 220 weekly CMS publications since Jul 20, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Jul 20, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.1513 (Sep 23, 2026) to a high of $32.9940 (Sep 14, 2022), with a median of $9.8370 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.9717 per ML — about 8% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 00781718670) is labeled by Sandoz Inc., and CMS classifies it as a generic product.