Back to Market Feed

Product Information

DIPHENHYDRAMINE 50 MG CAPSULE is a generic product labeled by Major Pharmaceuticals, priced at $0.0313 per EA under NDC 00904205661. Its NADAC has been published 665 times since Nov 28, 2013.

DIPHENHYDRAMINE 50 MG CAPSULE

Diphenhydramine Hydrochloride
$0.0313per EA
OTC

Strength

50 mg/1

NDC

00904205661

Classification

Generic

Dosage Form

CAPSULE

Route

ORAL

Effective Date

8/19/2026

Approval Type

OTC MONOGRAPH DRUG

FDA Application

M012

On Market Since

1/2/2009

Pharmacological Classes

Histamine H1 Receptor Antagonists
Histamine-1 Receptor Antagonist

Price Statistics

The NADAC for DIPHENHYDRAMINE 50 MG CAPSULE has been published 665 times since Nov 28, 2013, and over the history we have for it it has risen 58.9%. The table below summarizes its recorded NADAC range and movement.

Current price$0.0313 per EA
All-time high$0.0316 (Jul 15, 2026)
All-time low$0.0176 (May 19, 2021)
52-week high$0.0316
52-week low$0.0219
Median price$0.0225
Average price$0.0224
Largest weekly change+35.2% (Feb 23, 2022)
Weeks tracked665
Tracking sinceNov 28, 2013

Price History

1W

+1.9%

1M

+1.9%

3M

+28.2%

6M

+28.0%

1Y

+24.0%

3Y

+22.7%

5Y

+56.5%

All

+58.9%

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 21% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

Save up to 21%

1 alternative • Same active ingredient

DIPHENHYDRAMINE 50 MG CAPSULE
Generic
42806064910•Epic Pharma LLC
$0.0246
Save 21%

Related Drugs

Same classification

GS SLEEP TIME 50 MG/30 ML LIQ
Generic
00113018640•L. Perrigo Company
$0.0085
per ML
GNP SLEEP AID 50 MG/30 ML LIQ
Generic
46122075429•AmerisourceBergen
$0.0085
per ML
SLEEP AID 50 MG/30 ML LIQUID
Generic
70000017401•Cardinal Health
$0.0097
per ML
PV FLU RELIEF THERAPY LIQUID
Generic
68016015408•Chain Drug Marketing Association
$0.0121
per ML
SLEEP AID 50 MG/30 ML LIQUID
Generic
70000017402•Cardinal Health
$0.0136
per ML
QC EZZ NITE SLEEP 50 MG/30 ML
Generic
83324001506•Chain Drug Marketing Association
$0.0136
per ML
QC CHILD ALLERGY 12.5 MG/5 ML
Generic
63868082354•Chain Drug Marketing Association
$0.0155
per ML
CHILD ALLERGY RLF 12.5 MG/5 ML
Generic
70000069301•Cardinal Health
$0.0160
per ML
FT CHILD ALLERGY 12.5 MG/5 ML
Generic
70677101202•Strategic Sourcing Services LLC
$0.0160
per ML
CHILD ALLERGY RLF 12.5 MG/5 ML
Generic
82568001608•Aarna USA Inc.
$0.0160
per ML

Frequently asked questions

What is the NADAC price of DIPHENHYDRAMINE 50 MG CAPSULE?

The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 50 MG CAPSULE, manufactured by Major Pharmaceuticals, is $0.0313 per EA (NDC 00904205661), effective Aug 19, 2026.

How has the price of DIPHENHYDRAMINE 50 MG CAPSULE changed over time?

Over the history we have for it, the NADAC for DIPHENHYDRAMINE 50 MG CAPSULE has risen 58.9%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.

What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 50 MG CAPSULE?

Since Nov 28, 2013, the NADAC for DIPHENHYDRAMINE 50 MG CAPSULE has ranged from a low of $0.0176 (May 19, 2021) to a high of $0.0316 (Jul 15, 2026), with a median of $0.0225 per EA.

Are there cheaper alternatives to DIPHENHYDRAMINE 50 MG CAPSULE?

Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DIPHENHYDRAMINE 50 MG CAPSULE, is $0.0246 per EA — about 21% below DIPHENHYDRAMINE 50 MG CAPSULE.

Who manufactures DIPHENHYDRAMINE 50 MG CAPSULE?

DIPHENHYDRAMINE 50 MG CAPSULE (NDC 00904205661) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.