Diphenhydramine Hydrochloride
57 NDCs across 20 manufacturers|51 Generic,6 Brand
Diphenhydramine Hydrochloride is used to treat anxiety disorders, motion sickness, nausea, rhinitis, allergic, perennial, sleep initiation and maintenance disorders and sneezing, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982.
Diphenhydramine Hydrochloride is available as 57 NDCs from 20 manufacturers (51 generic, 6 brand), with NADAC prices from $0.02 to $0.35 per EA — the most expensive product costs about 14× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
57
51G / 6B
Manufacturers
20
competing in market
Price Spread
$0.02 – $0.35
per EA, 34 of 57 NDCs
7d Activity
avg -1.7% WoW · of 57 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Chain Drug Marketing Association manufacturer profile
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Lead class
Histamine-1 Receptor Antagonist class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
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Manufacturer Breakdown
20 manufacturers producing DIPHENHYDRAMINE HYDROCHLORIDE
Frequently Asked Questions
What is Diphenhydramine Hydrochloride used to treat?
Diphenhydramine Hydrochloride is used to treat anxiety disorders, motion sickness, nausea, rhinitis, allergic, perennial, sleep initiation and maintenance disorders and sneezing, per the National Library of Medicine's MED-RT classification.
When did Diphenhydramine Hydrochloride become available as a generic?
FDA approved the first generic Diphenhydramine Hydrochloride (ANDA) on Jan 1, 1982.
How many Diphenhydramine Hydrochloride products are on the market?
The Diphenhydramine Hydrochloride drug market contains 57 NDCs from 20 manufacturers — 51 generic and 6 brand products.
What is the price range for Diphenhydramine Hydrochloride?
NADAC reference prices for Diphenhydramine Hydrochloride range from $0.0246 to $0.3523 per EA — the most expensive product costs about 14× the cheapest. 23 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Is generic Diphenhydramine Hydrochloride cheaper than brand?
The average generic NADAC for Diphenhydramine Hydrochloride is $0.0535 per EA, versus $0.3523 for brand-labeled products — brand versions average about 6.6× the generic price.
Which manufacturers make Diphenhydramine Hydrochloride?
20 manufacturers list Diphenhydramine Hydrochloride in NADAC. Ranked by number of NDCs, the largest are Chain Drug Marketing Association (9), The Procter & Gamble Manufacturing Company (6), Cardinal Health (5), Major Pharmaceuticals (5), Topco Associates LLC (4).
How has the price of Diphenhydramine Hydrochloride changed recently?
Over the past 7 days, 1 Diphenhydramine Hydrochloride NDC rose and 36 fell, with a market-wide average change of -1.7%.