Product Information
METOLAZONE 2.5 MG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.2279 per EA under NDC 00904752061. Its NADAC has been published 32 times since Jan 14, 2026.
FDA first approved this application on Oct 24, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2.5 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904752061
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
METOLAZONEApproval Type
Generic (ANDA)
FDA Application
ANDA215616FDA Approved
10/24/2022
TE Code
AB
On Market Since
11/20/2025
Pharmacological Classes
Price Statistics
The NADAC for METOLAZONE 2.5 MG TABLET has been published 32 times since Jan 14, 2026, and over the history we have for it it has risen 7.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2279 per EA |
|---|---|
| All-time high | $0.2279 (Aug 19, 2026) |
| All-time low | $0.2129 (Jan 14, 2026) |
| 52-week high | $0.2279 |
| 52-week low | $0.2129 |
| Median price | $0.2234 |
| Average price | $0.2230 |
| Largest weekly change | +5.4% (Jan 21, 2026) |
| Weeks tracked | 32 |
| Tracking since | Jan 14, 2026 |
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METOLAZONE 2.5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for METOLAZONE 2.5 MG TABLET, manufactured by Major Pharmaceuticals, is $0.2279 per EA (NDC 00904752061), effective Aug 19, 2026.
How has the price of METOLAZONE 2.5 MG TABLET changed over time?
Over the history we have for it, the NADAC for METOLAZONE 2.5 MG TABLET has risen 7.0%. It has been tracked across 32 weekly CMS publications since Jan 14, 2026.
What are the highest and lowest recorded NADAC prices for METOLAZONE 2.5 MG TABLET?
Since Jan 14, 2026, the NADAC for METOLAZONE 2.5 MG TABLET has ranged from a low of $0.2129 (Jan 14, 2026) to a high of $0.2279 (Aug 19, 2026), with a median of $0.2234 per EA.
Are there cheaper alternatives to METOLAZONE 2.5 MG TABLET?
6 manufacturers publish a NADAC-priced product with the same active ingredient and strength as METOLAZONE 2.5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures METOLAZONE 2.5 MG TABLET?
METOLAZONE 2.5 MG TABLET (NDC 00904752061) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.