Metolazone
31 NDCs across 11 manufacturers|31 Generic,0 Brand
Metolazone is used to treat edema, heart failure, hypertension and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Dec 19, 2003. FDA's Orange Book lists 27 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $14 million on Metolazone across 646,000 claims for 212,000 beneficiaries.
Metolazone is available as 31 NDCs from 11 manufacturers (31 generic, 0 brand), with NADAC prices from $0.23 to $1.18 per EA — the most expensive product costs about 5.1× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
31
31G / 0B
Manufacturers
11
competing in market
Price Spread
$0.23 – $1.18
per EA
7d Activity
avg -2.4% WoW · of 31 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Explore this market from other angles
Move from the molecule page into the supplier, class, and trend views that create the strongest internal-link cluster for this market.
Top supplier
Sandoz Inc. manufacturer profile
Open the supplier page for the manufacturer with the strongest footprint in this market.
Lead class
Thiazide-like Diuretic class view
See how this market rolls up into the broader therapeutic class and compare other drugs in the same bucket.
Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
11 manufacturers producing METOLAZONE(1 pricing outlier)
Frequently Asked Questions
What is Metolazone used to treat?
Metolazone is used to treat edema, heart failure, hypertension and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
When did Metolazone become available as a generic?
FDA approved the first generic Metolazone (ANDA) on Dec 19, 2003. The Orange Book currently lists 27 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Metolazone?
In 2024, Medicare Part D spent $14 million on Metolazone across 646,000 claims for 212,000 beneficiaries.
How many Metolazone products are on the market?
The Metolazone drug market contains 31 NDCs from 11 manufacturers — 31 generic and 0 brand products.
What is the price range for Metolazone?
NADAC reference prices for Metolazone range from $0.2328 to $1.1811 per EA — the most expensive product costs about 5.1× the cheapest.
Which manufacturers make Metolazone?
11 manufacturers list Metolazone in NADAC. Ranked by number of NDCs, the largest are Sandoz Inc. (4), Alembic Pharmaceuticals Inc. (3), Ingenus Pharmaceuticals LLC (3), Amici Pharma, Inc (3), Method Pharmaceuticals LLC (3).
How has the price of Metolazone changed recently?
Over the past 7 days, 19 Metolazone NDCs rose and 10 fell, with a market-wide average change of -2.4%.