Metolazone
31 NDCs across 11 manufacturers|31 Generic,0 Brand
Metolazone is used to treat edema, heart failure, hypertension and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Dec 19, 2003. FDA's Orange Book lists 30 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $14 million on Metolazone across 646,000 claims for 212,000 beneficiaries.
Metolazone is available as 31 NDCs from 11 manufacturers (31 generic, 0 brand), with NADAC prices from $0.23 to $1.18 per EA — the most expensive product costs about 5.2× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
31
31G / 0B
Manufacturers
11
competing in market
Price Spread
$0.23 – $1.18
per EA
7d Activity
avg +0.6% WoW · of 31 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Manufacturer Breakdown
11 manufacturers producing METOLAZONE(1 pricing outlier)
Frequently Asked Questions
What is Metolazone used to treat?
Metolazone is used to treat edema, heart failure, hypertension and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
When did Metolazone become available as a generic?
FDA approved the first generic Metolazone (ANDA) on Dec 19, 2003. The Orange Book currently lists 30 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Metolazone?
In 2024, Medicare Part D spent $14 million on Metolazone across 646,000 claims for 212,000 beneficiaries.
How many Metolazone products are on the market?
The Metolazone drug market contains 31 NDCs from 11 manufacturers — 31 generic and 0 brand products.
What is the price range for Metolazone?
NADAC reference prices for Metolazone range from $0.2279 to $1.1811 per EA — the most expensive product costs about 5.2× the cheapest.
Which manufacturers make Metolazone?
11 manufacturers list Metolazone in NADAC. Ranked by number of NDCs, the largest are Sandoz Inc. (4), Method Pharmaceuticals LLC (3), Mylan Pharmaceuticals Inc. (3), Ingenus Pharmaceuticals LLC (3), Alembic Pharmaceuticals Inc. (3).
How has the price of Metolazone changed recently?
Over the past 7 days, 19 Metolazone NDCs rose and 11 fell, with a market-wide average change of +0.6%.