Product Information
ESTRADIOL 0.1% (0.5 MG) GEL PKT is a generic product labeled by Trigen Laboratories, LLC, priced at $0.9548 per EA under NDC 13811009132. Its NADAC has been published 172 times since Jun 21, 2023.
FDA first approved this application on Jun 4, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/.5g
Manufacturer
Trigen Laboratories, LLCNDC
13811009132
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA022038FDA Approved
6/4/2007
TE Code
AB
On Market Since
10/10/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has been published 172 times since Jun 21, 2023, and over the history we have for it it has declined 73.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9548 per EA |
|---|---|
| All-time high | $3.9353 (Sep 13, 2023) |
| All-time low | $0.9548 (Sep 23, 2026) |
| 52-week high | $2.0017 |
| 52-week low | $0.9548 |
| Median price | $1.9829 |
| Average price | $2.2027 |
| Largest weekly change | -47.1% (Apr 17, 2024) |
| Weeks tracked | 172 |
| Tracking since | Jun 21, 2023 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Trigen Laboratories, LLC manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.5 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.5 MG) GEL PKT, manufactured by Trigen Laboratories, LLC, is $0.9548 per EA (NDC 13811009132), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.5 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has declined 73.4%. It has been tracked across 172 weekly CMS publications since Jun 21, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.5 MG) GEL PKT?
Since Jun 21, 2023, the NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has ranged from a low of $0.9548 (Sep 23, 2026) to a high of $3.9353 (Sep 13, 2023), with a median of $1.9829 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.5 MG) GEL PKT?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (0.5 MG) GEL PKT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.5 MG) GEL PKT?
ESTRADIOL 0.1% (0.5 MG) GEL PKT (NDC 13811009132) is labeled by Trigen Laboratories, LLC, and CMS classifies it as a generic product.