Product Information
ESTRADIOL 0.1% (0.5 MG) GEL PKT is a generic product labeled by Trigen Laboratories, LLC, priced at $1.0336 per EA under NDC 13811009132. Its NADAC has been published 166 times since Jun 21, 2023.
FDA first approved this application on Jun 4, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/.5g
Manufacturer
Trigen Laboratories, LLCNDC
13811009132
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA022038FDA Approved
6/4/2007
TE Code
AB
On Market Since
10/10/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has been published 166 times since Jun 21, 2023, and over the history we have for it it has declined 71.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.0336 per EA |
|---|---|
| All-time high | $3.9353 (Sep 13, 2023) |
| All-time low | $1.0336 (Aug 19, 2026) |
| 52-week high | $2.1669 |
| 52-week low | $1.0336 |
| Median price | $1.9962 |
| Average price | $2.2459 |
| Largest weekly change | -47.1% (Apr 17, 2024) |
| Weeks tracked | 166 |
| Tracking since | Jun 21, 2023 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.5 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.5 MG) GEL PKT, manufactured by Trigen Laboratories, LLC, is $1.0336 per EA (NDC 13811009132), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.1% (0.5 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has declined 71.2%. It has been tracked across 166 weekly CMS publications since Jun 21, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.5 MG) GEL PKT?
Since Jun 21, 2023, the NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has ranged from a low of $1.0336 (Aug 19, 2026) to a high of $3.9353 (Sep 13, 2023), with a median of $1.9962 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.5 MG) GEL PKT?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (0.5 MG) GEL PKT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.5 MG) GEL PKT?
ESTRADIOL 0.1% (0.5 MG) GEL PKT (NDC 13811009132) is labeled by Trigen Laboratories, LLC, and CMS classifies it as a generic product.