Estradiol

Estradiol is used to treat breast neoplasms, hot flashes, hypogonadism, premature menopause, menorrhagia and primary ovarian insufficiency, per the National Library of Medicine's MED-RT classification. The brand product was first FDA-approved on Sep 10, 1986, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 116 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $392 million on Estradiol across 5.1 million claims for 1.9 million beneficiaries.

Estradiol is available as 148 NDCs from 27 manufacturers (116 generic, 32 brand), with NADAC prices from $0.06 to $551.32 per EA — the most expensive product costs about 8,943× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.