Drug Markets/Estradiol

Estradiol

Brand names: Estrace, Climara, Vivelle-Dot, Estring

148 NDCs across 27 manufacturers|116 Generic,32 Brand

Estradiol is the primary human estrogen, prescribed for menopausal symptoms, and in some cases for osteoporosis prevention and gender-affirming therapy. This market is unusually heterogeneous: oral tablets (Estrace equivalents), transdermal patches (Climara, Vivelle-Dot), topical gels, vaginal creams, and the vaginal ring (Estring) all share the same active ingredient but are priced per tablet, per patch, per gram, or per ring. Comparing per-unit NADAC across those forms is not meaningful — compare within a dosage form instead.

▸ More about this market

Estradiol is used to treat breast neoplasms, hot flashes, hypogonadism, premature menopause, menorrhagia and primary ovarian insufficiency, per the National Library of Medicine's MED-RT classification. The brand product was first FDA-approved on Sep 10, 1986, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 116 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $392 million on Estradiol across 5.1 million claims for 1.9 million beneficiaries.

Estradiol is available as 148 NDCs from 27 manufacturers (116 generic, 32 brand), with NADAC prices from $0.06 to $551.19 per EAthe most expensive product costs about 9,066× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

148

116G / 32B

Manufacturers

27

competing in market

Price Spread

$0.06 – $551.19

per EA, 126 of 148 NDCs

7d Activity

58827 flat

avg -2.9% WoW · of 148 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Drug Portfolio

148 NDCs total, 148 shown

Drug Price 7d Change
ESTRING 7.5 MCG/DAY (2 MG) RING
$551.1881
per EA
-0.03%
MENOSTAR 14 MCG/DAY PATCH
$38.7375
per EA
-0.06%
IMVEXXY 4 MCG STARTER PACK
$27.1090
per EA
IMVEXXY 4 MCG MAINTENANCE PACK
$27.0962
per EA
IMVEXXY 10 MCG MAINTENANCE PAK
$27.0902
per EA
IMVEXXY 10 MCG STARTER PACK
$27.0553
per EA
VAGIFEM 10 MCG VAGINAL TAB
$20.3235
per EA
-0.01%
VAGIFEM 10 MCG VAGINAL TAB
$20.3235
per EA
-0.01%
VIVELLE-DOT 0.075 MG PATCH
$18.4289
per EA
+0.01%
VIVELLE-DOT 0.05 MG PATCH
$18.4026
per EA
-0.02%
VIVELLE-DOT 0.1 MG PATCH
$18.3937
per EA
-0.02%
VIVELLE-DOT 0.025 MG PATCH
$18.3846
per EA
-0.06%
VIVELLE-DOT 0.0375 MG PATCH
$18.3745
per EA
-0.04%
CLIMARA 0.1 MG/DAY PATCH
$18.3102
per EA
+0.07%
CLIMARA 0.0375 MG/DAY PATCH
$18.2986
per EA
+0.03%
CLIMARA 0.075 MG/DAY PATCH
$18.2974
per EA
+0.11%
CLIMARA 0.05 MG/DAY PATCH
$18.2693
per EA
+0.02%
EVAMIST 1.53 MG/SPRAY
$18.2666
per ML
+0.06%
CLIMARA 0.025 MG/DAY PATCH
$18.2519
per EA
+0.02%
CLIMARA 0.06 MG/DAY PATCH
$18.1809
per EA
-0.02%
ESTRADIOL 0.075 MG PATCH(1/WK)
$12.4786
per EA
+2.70%
ESTRADIOL 0.075 MG PATCH(1/WK)
$12.4786
per EA
+2.70%
ESTRADIOL 0.1 MG PATCH (1/WK)
$12.3611
per EA
-1.41%
ESTRADIOL 0.1 MG PATCH (1/WK)
$12.3611
per EA
-1.41%
ESTRADIOL 0.06 MG PATCH (1/WK)
$12.0009
per EA
-2.39%
ESTRADIOL 0.06 MG PATCH (1/WK)
$12.0009
per EA
-2.39%
MINIVELLE 0.05 MG PATCH
$11.5871
per EA
-0.01%
MINIVELLE 0.0375 MG PATCH
$11.5842
per EA
+0.11%
MINIVELLE 0.025 MG PATCH
$11.5831
per EA
+0.03%
MINIVELLE 0.1 MG PATCH
$11.5766
per EA
0.00%
MINIVELLE 0.075 MG PATCH
$11.5743
per EA
ESTRADIOL 0.0375 MG PATCH(1/WK)
$11.4740
per EA
+0.48%
ESTRADIOL 0.0375 MG PATCH(1/WK)
$11.4740
per EA
+0.48%
ESTRADIOL 0.025 MG PATCH(1/WK)
$11.3932
per EA
+0.46%
ESTRADIOL 0.025 MG PATCH(1/WK)
$11.3932
per EA
+0.46%
ESTRADIOL 0.05 MG PATCH (1/WK)
$10.8027
per EA
+1.61%
ESTRADIOL 0.05 MG PATCH (1/WK)
$10.8027
per EA
+1.61%
ESTRADIOL 0.1 MG PATCH (2/WK)
$8.2292
per EA
+6.26%
ESTRADIOL 0.1 MG PATCH (2/WK)
$8.2292
per EA
+6.26%
ESTRADIOL 0.1 MG PATCH (2/WK)
$8.2292
per EA
+6.26%
LYLLANA 0.1 MG PATCH
$8.2292
per EA
+6.26%
ESTRADIOL 0.1 MG PATCH (2/WK)
$8.2292
per EA
+6.26%
ESTRADIOL 0.1 MG PATCH (2/WK)
$8.2292
per EA
+6.26%
DOTTI 0.1 MG PATCH
$8.2292
per EA
+6.26%
ESTRADIOL 0.0375 MG PATCH(2/WK)
$8.2278
per EA
+2.48%
ESTRADIOL 0.0375 MG PATCH(2/WK)
$8.2278
per EA
+2.48%
ESTRADIOL 0.0375 MG PATCH(2/WK)
$8.2278
per EA
+2.48%
ESTRADIOL 0.0375 MG PATCH(2/WK)
$8.2278
per EA
+2.48%
ESTRADIOL 0.0375 MG PATCH(2/WK)
$8.2278
per EA
+2.48%
LYLLANA 0.0375 MG PATCH
$8.2278
per EA
+2.48%
DOTTI 0.0375 MG PATCH
$8.2278
per EA
+2.48%
DOTTI 0.05 MG PATCH
$8.2223
per EA
+3.08%
LYLLANA 0.05 MG PATCH
$8.2223
per EA
+3.08%
ESTRADIOL 0.05 MG PATCH (2/WK)
$8.2223
per EA
+3.08%
ESTRADIOL 0.05 MG PATCH (2/WK)
$8.2223
per EA
+3.08%
ESTRADIOL 0.05 MG PATCH (2/WK)
$8.2223
per EA
+3.08%
ESTRADIOL 0.05 MG PATCH (2/WK)
$8.2223
per EA
+3.08%
ESTRADIOL 0.05 MG PATCH (2/WK)
$8.2223
per EA
+3.08%
ESTRADIOL 0.075 MG PATCH(2/WK)
$8.0918
per EA
+5.18%
LYLLANA 0.075 MG PATCH
$8.0918
per EA
+5.18%
DOTTI 0.075 MG PATCH
$8.0918
per EA
+5.18%
ESTRADIOL 0.075 MG PATCH(2/WK)
$8.0918
per EA
+5.18%
ESTRADIOL 0.075 MG PATCH(2/WK)
$8.0918
per EA
+5.18%
ESTRADIOL 0.075 MG PATCH(2/WK)
$8.0918
per EA
+5.18%
ESTRADIOL 0.075 MG PATCH(2/WK)
$8.0918
per EA
+5.18%
ESTRACE 0.01% CREAM
$7.7613
per GM
-0.17%
DOTTI 0.025 MG PATCH
$7.6199
per EA
-2.69%
ESTRADIOL 0.025 MG PATCH(2/WK)
$7.6199
per EA
-2.69%
ESTRADIOL 0.025 MG PATCH(2/WK)
$7.6199
per EA
-2.69%
ESTRADIOL 0.025 MG PATCH(2/WK)
$7.6199
per EA
-2.69%
ESTRADIOL 0.025 MG PATCH(2/WK)
$7.6199
per EA
-2.69%
LYLLANA 0.025 MG PATCH
$7.6199
per EA
-2.69%
ESTRADIOL 0.025 MG PATCH(2/WK)
$7.6199
per EA
-2.69%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
YUVAFEM 10 MCG VAGINAL INSERT
$5.6451
per EA
-4.52%
YUVAFEM 10 MCG VAGINAL INSERT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
ESTRADIOL 10 MCG VAGINAL INSRT
$5.6451
per EA
-4.52%
DIVIGEL 0.5 MG GEL PACKET
$5.4149
per EA
-0.20%
DIVIGEL 0.75 MG GEL PACKET
$5.3993
per EA
DIVIGEL 0.25 MG GEL PACKET
$5.3877
per EA
+0.02%
DIVIGEL 1 MG GEL PACKET
$5.3728
per GM
+0.07%
DIVIGEL 1.25 MG GEL PACKET
$4.2906
per GM
ELESTRIN 0.06% GEL
$3.6099
per GM
-0.04%
ESTRADIOL 0.06% 1.25G GEL PUMP
$3.4144
per GM
-2.64%
ESTRADIOL 0.06% 1.25G GEL PUMP
$3.4144
per GM
-2.64%
ESTRADIOL 0.1% (1 MG) GEL PKT
$1.1272
per GM
-12.02%
ESTRADIOL 0.1% (1 MG) GEL PKT
$1.1272
per GM
-12.02%
ESTRADIOL 0.1% (1 MG) GEL PKT
$1.1272
per GM
-12.02%
ESTRADIOL 0.1% (1 MG) GEL PKT
$1.1272
per GM
-12.02%
ESTRADIOL 0.1% (1 MG) GEL PKT
$1.1272
per GM
-12.02%
ESTRADIOL 0.1% (0.5 MG) GEL PKT
$1.0336
per EA
-17.36%
ESTRADIOL 0.1% (0.5 MG) GEL PKT
$1.0336
per EA
-17.36%
ESTRADIOL 0.1% (0.5 MG) GEL PKT
$1.0336
per EA
-17.36%
ESTRADIOL 0.1% (0.5 MG) GEL PKT
$1.0336
per EA
-17.36%
ESTRADIOL 0.1% (0.5 MG) GEL PKT
$1.0336
per EA
-17.36%
ESTRADIOL 0.1% (0.25 MG) GEL PK
$0.8636
per EA
-24.21%
ESTRADIOL 0.1% (0.25 MG) GEL PK
$0.8636
per EA
-24.21%
ESTRADIOL 0.1% (0.25 MG) GEL PK
$0.8636
per EA
-24.21%
ESTRADIOL 0.1% (0.25 MG) GEL PK
$0.8636
per EA
-24.21%
ESTRADIOL 0.1% (0.25 MG) GEL PK
$0.8636
per EA
-24.21%
ESTRADIOL 0.1% (1.25 MG) GEL PK
$0.8042
per GM
-21.07%
ESTRADIOL 0.1% (1.25 MG) GEL PK
$0.8042
per GM
-21.07%
ESTRADIOL 0.1% (1.25 MG) GEL PK
$0.8042
per GM
-21.07%
ESTRADIOL 0.1% (1.25 MG) GEL PK
$0.8042
per GM
-21.07%
ESTRADIOL 0.1% (1.25 MG) GEL PK
$0.8042
per GM
-21.07%
ESTRADIOL 0.1% (0.75 MG) GEL PK
$0.7544
per EA
-25.83%
ESTRADIOL 0.1% (0.75 MG) GEL PK
$0.7544
per EA
-25.83%
ESTRADIOL 0.1% (0.75 MG) GEL PK
$0.7544
per EA
-25.83%
ESTRADIOL 0.1% (0.75 MG) GEL PK
$0.7544
per EA
-25.83%
ESTRADIOL 0.1% (0.75 MG) GEL PK
$0.7544
per EA
-25.83%
ESTRADIOL 0.01% CREAM
$0.4257
per GM
+11.97%
ESTRADIOL 0.01% CREAM
$0.4257
per GM
+11.97%
ESTRADIOL 0.01% CREAM
$0.4257
per GM
+11.97%
ESTRADIOL 0.01% CREAM
$0.4257
per GM
+11.97%
ESTRADIOL 0.01% CREAM
$0.4257
per GM
+11.97%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 2 MG TABLET
$0.0797
per EA
-1.94%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 1 MG TABLET
$0.0636
per EA
-1.12%
ESTRADIOL 0.5 MG TABLET
$0.0608
per EA
+1.83%
ESTRADIOL 0.5 MG TABLET
$0.0608
per EA
+1.83%
ESTRADIOL 0.5 MG TABLET
$0.0608
per EA
+1.83%
ESTRADIOL 0.5 MG TABLET
$0.0608
per EA
+1.83%
ESTRADIOL 0.5 MG TABLET
$0.0608
per EA
+1.83%
ESTRADIOL 0.5 MG TABLET
$0.0608
per EA
+1.83%

Frequently Asked Questions

What is Estradiol used to treat?

Estradiol is used to treat breast neoplasms, hot flashes, hypogonadism, premature menopause, menorrhagia and primary ovarian insufficiency, per the National Library of Medicine's MED-RT classification.

When did Estradiol become available as a generic?

FDA approved the first generic Estradiol (ANDA) on Jan 1, 1982. The Orange Book currently lists 116 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Estradiol?

In 2024, Medicare Part D spent $392 million on Estradiol across 5.1 million claims for 1.9 million beneficiaries.

How many Estradiol products are on the market?

The Estradiol drug market contains 148 NDCs from 27 manufacturers — 116 generic and 32 brand products.

What is the price range for Estradiol?

NADAC reference prices for Estradiol range from $0.0608 to $551.1881 per EA — the most expensive product costs about 9,066× the cheapest. 22 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Is generic Estradiol cheaper than brand?

The average generic NADAC for Estradiol is $5.0033 per EA, versus $37.5786 for brand-labeled products — brand versions average about 7.5× the generic price.

Which manufacturers make Estradiol?

27 manufacturers list Estradiol in NADAC. Ranked by number of NDCs, the largest are Mylan Pharmaceuticals Inc. (17), Sandoz Inc. (16), Amneal Pharmaceuticals LLC (12), NorthStar Rx LLC (12), ANI Pharmaceuticals, Inc. (11).

How has the price of Estradiol changed recently?

Over the past 7 days, 58 Estradiol NDCs rose and 82 fell, with a market-wide average change of -2.9%.