Product Information
EPLERENONE 50 MG TABLET is a generic product labeled by Rising Pharma Holdings Inc., priced at $0.4504 per EA under NDC 16571017409. Its NADAC has been published 73 times since May 14, 2025.
FDA first approved this application on Mar 23, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/1
Manufacturer
Rising Pharma Holdings Inc.NDC
16571017409
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
EPLERENONEApproval Type
Generic (ANDA)
FDA Application
ANDA214663FDA Approved
3/23/2022
TE Code
AB
On Market Since
9/30/2024
Pharmacological Classes
Price Statistics
The NADAC for EPLERENONE 50 MG TABLET has been published 73 times since May 14, 2025, and over the history we have for it it has declined 25.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4504 per EA |
|---|---|
| All-time high | $0.6037 (May 14, 2025) |
| All-time low | $0.4504 (Sep 23, 2026) |
| 52-week high | $0.5195 |
| 52-week low | $0.4504 |
| Median price | $0.4729 |
| Average price | $0.4939 |
| Largest weekly change | -7.1% (Jun 18, 2025) |
| Weeks tracked | 73 |
| Tracking since | May 14, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Rising Pharma Holdings Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Eplerenone market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Aldosterone Antagonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of EPLERENONE 50 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for EPLERENONE 50 MG TABLET, manufactured by Rising Pharma Holdings Inc., is $0.4504 per EA (NDC 16571017409), effective Sep 30, 2026.
How has the price of EPLERENONE 50 MG TABLET changed over time?
Over the history we have for it, the NADAC for EPLERENONE 50 MG TABLET has declined 25.4%. It has been tracked across 73 weekly CMS publications since May 14, 2025.
What are the highest and lowest recorded NADAC prices for EPLERENONE 50 MG TABLET?
Since May 14, 2025, the NADAC for EPLERENONE 50 MG TABLET has ranged from a low of $0.4504 (Sep 23, 2026) to a high of $0.6037 (May 14, 2025), with a median of $0.4729 per EA.
Are there cheaper alternatives to EPLERENONE 50 MG TABLET?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as EPLERENONE 50 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures EPLERENONE 50 MG TABLET?
EPLERENONE 50 MG TABLET (NDC 16571017409) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.