Product Information
BUPROPION HCL XL 300 MG TABLET is a generic product labeled by Accord Healthcare Inc., priced at $0.1014 per EA under NDC 16729044410. Its NADAC has been published 384 times since Apr 17, 2019.
FDA first approved this application on Oct 31, 2018. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
300 mg/1
Manufacturer
Accord Healthcare Inc.NDC
16729044410
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA210497FDA Approved
10/31/2018
TE Code
AB3
On Market Since
3/25/2019
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL XL 300 MG TABLET has been published 384 times since Apr 17, 2019, and over the history we have for it it has declined 73.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1014 per EA |
|---|---|
| All-time high | $0.4702 (Sep 11, 2019) |
| All-time low | $0.1014 (Aug 19, 2026) |
| 52-week high | $0.1492 |
| 52-week low | $0.1014 |
| Median price | $0.1741 |
| Average price | $0.1941 |
| Largest weekly change | -33.9% (Sep 18, 2019) |
| Weeks tracked | 384 |
| Tracking since | Apr 17, 2019 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BUPROPION HCL XL 300 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL XL 300 MG TABLET, manufactured by Accord Healthcare Inc., is $0.1014 per EA (NDC 16729044410), effective Aug 19, 2026.
How has the price of BUPROPION HCL XL 300 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL XL 300 MG TABLET has declined 73.5%. It has been tracked across 384 weekly CMS publications since Apr 17, 2019.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL XL 300 MG TABLET?
Since Apr 17, 2019, the NADAC for BUPROPION HCL XL 300 MG TABLET has ranged from a low of $0.1014 (Aug 19, 2026) to a high of $0.4702 (Sep 11, 2019), with a median of $0.1741 per EA.
Are there cheaper alternatives to BUPROPION HCL XL 300 MG TABLET?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL XL 300 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL XL 300 MG TABLET?
BUPROPION HCL XL 300 MG TABLET (NDC 16729044410) is labeled by Accord Healthcare Inc., and CMS classifies it as a generic product.