Product Information
BUPROPION HCL SR 100 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $0.0679 per EA under NDC 42806042401. Its NADAC has been published 73 times since May 14, 2025.
FDA first approved this application on Oct 16, 2018. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
100 mg/1
Manufacturer
Epic Pharma LLCNDC
42806042401
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA211347FDA Approved
10/16/2018
TE Code
AB1
On Market Since
9/18/2023
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL SR 100 MG TABLET has been published 73 times since May 14, 2025, and over the history we have for it it has declined 29.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0679 per EA |
|---|---|
| All-time high | $0.0964 (Jun 11, 2025) |
| All-time low | $0.0639 (Oct 22, 2025) |
| 52-week high | $0.0752 |
| 52-week low | $0.0639 |
| Median price | $0.0713 |
| Average price | $0.0755 |
| Largest weekly change | -14.6% (Oct 22, 2025) |
| Weeks tracked | 73 |
| Tracking since | May 14, 2025 |
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
bupropion hydrochloride market comparison
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Therapeutic class
Aminoketone class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPROPION HCL SR 100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL SR 100 MG TABLET, manufactured by Epic Pharma LLC, is $0.0679 per EA (NDC 42806042401), effective Sep 30, 2026.
How has the price of BUPROPION HCL SR 100 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL SR 100 MG TABLET has declined 29.0%. It has been tracked across 73 weekly CMS publications since May 14, 2025.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL SR 100 MG TABLET?
Since May 14, 2025, the NADAC for BUPROPION HCL SR 100 MG TABLET has ranged from a low of $0.0639 (Oct 22, 2025) to a high of $0.0964 (Jun 11, 2025), with a median of $0.0713 per EA.
Are there cheaper alternatives to BUPROPION HCL SR 100 MG TABLET?
7 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL SR 100 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL SR 100 MG TABLET?
BUPROPION HCL SR 100 MG TABLET (NDC 42806042401) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.