Product Information
FLUOROURACIL 5% CREAM is a generic product labeled by Accord Healthcare Inc., priced at $0.5918 per GM under NDC 16729054235. Its NADAC has been published 218 times since Mar 23, 2022.
FDA first approved this application on Oct 7, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/g
Manufacturer
Accord Healthcare Inc.NDC
16729054235
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
5/20/2026
Active Ingredients
FLUOROURACILApproval Type
Generic (ANDA)
FDA Application
ANDA214845FDA Approved
10/7/2021
TE Code
AB
On Market Since
11/11/2021
Pharmacological Classes
Price Statistics
The NADAC for FLUOROURACIL 5% CREAM has been published 218 times since Mar 23, 2022, and over the history we have for it it has declined 58.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5918 per GM |
|---|---|
| All-time high | $1.4274 (Apr 13, 2022) |
| All-time low | $0.5918 (May 20, 2026) |
| 52-week high | $0.7378 |
| 52-week low | $0.5918 |
| Median price | $0.7382 |
| Average price | $0.8080 |
| Largest weekly change | +30.8% (Nov 22, 2023) |
| Weeks tracked | 218 |
| Tracking since | Mar 23, 2022 |
1W
N/A
1M
N/A
3M
N/A
6M
-3.4%
1Y
-19.8%
3Y
-18.8%
5Y
N/A
All
-58.5%
Last surveyed May 20, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of FLUOROURACIL 5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for FLUOROURACIL 5% CREAM, manufactured by Accord Healthcare Inc., is $0.5918 per GM (NDC 16729054235), effective May 20, 2026.
How has the price of FLUOROURACIL 5% CREAM changed over time?
Over the history we have for it, the NADAC for FLUOROURACIL 5% CREAM has declined 58.5%. It has been tracked across 218 weekly CMS publications since Mar 23, 2022.
What are the highest and lowest recorded NADAC prices for FLUOROURACIL 5% CREAM?
Since Mar 23, 2022, the NADAC for FLUOROURACIL 5% CREAM has ranged from a low of $0.5918 (May 20, 2026) to a high of $1.4274 (Apr 13, 2022), with a median of $0.7382 per GM.
Are there cheaper alternatives to FLUOROURACIL 5% CREAM?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as FLUOROURACIL 5% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures FLUOROURACIL 5% CREAM?
FLUOROURACIL 5% CREAM (NDC 16729054235) is labeled by Accord Healthcare Inc., and CMS classifies it as a generic product.