Product Information
MESALAMINE 4 GM/60 ML ENEMA is a generic product labeled by Encube Ethicals, Inc., priced at $0.1759 per ML under NDC 21922004549. Its NADAC has been published 124 times since May 22, 2024.
FDA first approved this application on May 30, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 g/60mL
Manufacturer
Encube Ethicals, Inc.NDC
21922004549
Classification
Generic
Dosage Form
SUSPENSION
Route
RECTAL
Effective Date
9/23/2026
Active Ingredients
MESALAMINEApproval Type
Generic (ANDA)
FDA Application
ANDA216941FDA Approved
5/30/2023
TE Code
AB
On Market Since
6/1/2023
Pharmacological Classes
Price Statistics
The NADAC for MESALAMINE 4 GM/60 ML ENEMA has been published 124 times since May 22, 2024, and over the history we have for it it has declined 9.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1759 per ML |
|---|---|
| All-time high | $0.1965 (Jul 10, 2024) |
| All-time low | $0.1662 (Jan 21, 2026) |
| 52-week high | $0.1839 |
| 52-week low | $0.1662 |
| Median price | $0.1813 |
| Average price | $0.1819 |
| Largest weekly change | -8.3% (Jan 21, 2026) |
| Weeks tracked | 124 |
| Tracking since | May 22, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 44% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Mesalamine market comparison
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Therapeutic class
Aminosalicylate class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of MESALAMINE 4 GM/60 ML ENEMA?
The current National Average Drug Acquisition Cost (NADAC) for MESALAMINE 4 GM/60 ML ENEMA, manufactured by Encube Ethicals, Inc., is $0.1759 per ML (NDC 21922004549), effective Sep 30, 2026.
How has the price of MESALAMINE 4 GM/60 ML ENEMA changed over time?
Over the history we have for it, the NADAC for MESALAMINE 4 GM/60 ML ENEMA has declined 9.7%. It has been tracked across 124 weekly CMS publications since May 22, 2024.
What are the highest and lowest recorded NADAC prices for MESALAMINE 4 GM/60 ML ENEMA?
Since May 22, 2024, the NADAC for MESALAMINE 4 GM/60 ML ENEMA has ranged from a low of $0.1662 (Jan 21, 2026) to a high of $0.1965 (Jul 10, 2024), with a median of $0.1813 per ML.
Are there cheaper alternatives to MESALAMINE 4 GM/60 ML ENEMA?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, MESALAMINE 4 GM/60 ML ENEMA, is $0.0984 per ML — about 44% below MESALAMINE 4 GM/60 ML ENEMA.
Who manufactures MESALAMINE 4 GM/60 ML ENEMA?
MESALAMINE 4 GM/60 ML ENEMA (NDC 21922004549) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.