Product Information
MESALAMINE 4 GM/60 ML ENEMA is a generic product labeled by Encube Ethicals, Inc., priced at $0.1789 per ML under NDC 21922004549. Its NADAC has been published 118 times since May 22, 2024.
FDA first approved this application on May 30, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 g/60mL
Manufacturer
Encube Ethicals, Inc.NDC
21922004549
Classification
Generic
Dosage Form
SUSPENSION
Route
RECTAL
Effective Date
8/19/2026
Active Ingredients
MESALAMINEApproval Type
Generic (ANDA)
FDA Application
ANDA216941FDA Approved
5/30/2023
TE Code
AB
On Market Since
6/1/2023
Pharmacological Classes
Price Statistics
The NADAC for MESALAMINE 4 GM/60 ML ENEMA has been published 118 times since May 22, 2024, and over the history we have for it it has declined 8.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1789 per ML |
|---|---|
| All-time high | $0.1965 (Jul 10, 2024) |
| All-time low | $0.1662 (Jan 21, 2026) |
| 52-week high | $0.1839 |
| 52-week low | $0.1662 |
| Median price | $0.1814 |
| Average price | $0.1821 |
| Largest weekly change | -8.3% (Jan 21, 2026) |
| Weeks tracked | 118 |
| Tracking since | May 22, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 46% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of MESALAMINE 4 GM/60 ML ENEMA?
The current National Average Drug Acquisition Cost (NADAC) for MESALAMINE 4 GM/60 ML ENEMA, manufactured by Encube Ethicals, Inc., is $0.1789 per ML (NDC 21922004549), effective Aug 19, 2026.
How has the price of MESALAMINE 4 GM/60 ML ENEMA changed over time?
Over the history we have for it, the NADAC for MESALAMINE 4 GM/60 ML ENEMA has declined 8.1%. It has been tracked across 118 weekly CMS publications since May 22, 2024.
What are the highest and lowest recorded NADAC prices for MESALAMINE 4 GM/60 ML ENEMA?
Since May 22, 2024, the NADAC for MESALAMINE 4 GM/60 ML ENEMA has ranged from a low of $0.1662 (Jan 21, 2026) to a high of $0.1965 (Jul 10, 2024), with a median of $0.1814 per ML.
Are there cheaper alternatives to MESALAMINE 4 GM/60 ML ENEMA?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, MESALAMINE 4 GM/60 ML ENEMA, is $0.0974 per ML — about 46% below MESALAMINE 4 GM/60 ML ENEMA.
Who manufactures MESALAMINE 4 GM/60 ML ENEMA?
MESALAMINE 4 GM/60 ML ENEMA (NDC 21922004549) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.