Product Information
FLUOROURACIL 5% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.6034 per GM under NDC 21922004917. Its NADAC has been published 58 times since Jul 16, 2025.
FDA first approved this application on Feb 12, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2 g/40g
Manufacturer
Encube Ethicals, Inc.NDC
21922004917
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
FLUOROURACILApproval Type
Generic (ANDA)
FDA Application
ANDA216942FDA Approved
2/12/2025
TE Code
AB
On Market Since
2/14/2025
Pharmacological Classes
Price Statistics
The NADAC for FLUOROURACIL 5% CREAM has been published 58 times since Jul 16, 2025, and over the history we have for it it has declined 15.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.6034 per GM |
|---|---|
| All-time high | $0.7382 (Aug 13, 2025) |
| All-time low | $0.5853 (Jul 22, 2026) |
| 52-week high | $0.7378 |
| 52-week low | $0.5853 |
| Median price | $0.6154 |
| Average price | $0.6344 |
| Largest weekly change | -7.1% (Sep 17, 2025) |
| Weeks tracked | 58 |
| Tracking since | Jul 16, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of FLUOROURACIL 5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for FLUOROURACIL 5% CREAM, manufactured by Encube Ethicals, Inc., is $0.6034 per GM (NDC 21922004917), effective Aug 19, 2026.
How has the price of FLUOROURACIL 5% CREAM changed over time?
Over the history we have for it, the NADAC for FLUOROURACIL 5% CREAM has declined 15.3%. It has been tracked across 58 weekly CMS publications since Jul 16, 2025.
What are the highest and lowest recorded NADAC prices for FLUOROURACIL 5% CREAM?
Since Jul 16, 2025, the NADAC for FLUOROURACIL 5% CREAM has ranged from a low of $0.5853 (Jul 22, 2026) to a high of $0.7382 (Aug 13, 2025), with a median of $0.6154 per GM.
Are there cheaper alternatives to FLUOROURACIL 5% CREAM?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as FLUOROURACIL 5% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures FLUOROURACIL 5% CREAM?
FLUOROURACIL 5% CREAM (NDC 21922004917) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.