This NDC is on FDA's drug shortage list (posted Dec 15, 2021)
Reported reason: Shortage of an active ingredient
Product Information
METHYLPREDNISOLONE 400 MG/5 ML is a generic product labeled by Sagent Pharmaceuticals, priced at $13.0533 per ML under NDC 25021082105. Its NADAC has been published 87 times since Sep 18, 2024.
FDA first approved this application on Jun 27, 2018. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
80 mg/mL
Manufacturer
Sagent PharmaceuticalsNDC
25021082105
Classification
Generic
Dosage Form
INJECTION, SUSPENSION
Route
INTRA-ARTICULAR; INTRALESIONAL; INTRAMUSCULAR; INTRASYNOVIAL; SOFT TISSUE
Effective Date
5/21/2025
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA201835FDA Approved
6/27/2018
TE Code
AB
On Market Since
11/15/2021
Pharmacological Classes
Price Statistics
The NADAC for METHYLPREDNISOLONE 400 MG/5 ML has been published 87 times since Sep 18, 2024, and over the history we have for it it has declined 12.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $13.0533 per ML |
|---|---|
| All-time high | $14.9732 (Oct 16, 2024) |
| All-time low | $13.0533 (May 21, 2025) |
| 52-week high | $13.0533 |
| 52-week low | $13.0533 |
| Median price | $13.0533 |
| Average price | $13.4333 |
| Largest weekly change | -5.1% (Oct 23, 2024) |
| Weeks tracked | 87 |
| Tracking since | Sep 18, 2024 |
1W
N/A
1M
N/A
3M
N/A
6M
0.0%
1Y
0.0%
3Y
N/A
5Y
N/A
All
-12.8%
Last surveyed May 13, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 17% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Sagent Pharmaceuticals manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
methylprednisolone acetate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of METHYLPREDNISOLONE 400 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for METHYLPREDNISOLONE 400 MG/5 ML, manufactured by Sagent Pharmaceuticals, is $13.0533 per ML (NDC 25021082105), effective May 13, 2026.
How has the price of METHYLPREDNISOLONE 400 MG/5 ML changed over time?
Over the history we have for it, the NADAC for METHYLPREDNISOLONE 400 MG/5 ML has declined 12.8%. It has been tracked across 87 weekly CMS publications since Sep 18, 2024.
What are the highest and lowest recorded NADAC prices for METHYLPREDNISOLONE 400 MG/5 ML?
Since Sep 18, 2024, the NADAC for METHYLPREDNISOLONE 400 MG/5 ML has ranged from a low of $13.0533 (May 21, 2025) to a high of $14.9732 (Oct 16, 2024), with a median of $13.0533 per ML.
Are there cheaper alternatives to METHYLPREDNISOLONE 400 MG/5 ML?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DEPO-MEDROL 400 MG/5 ML VIAL, is $10.8023 per ML — about 17% below METHYLPREDNISOLONE 400 MG/5 ML.
Who manufactures METHYLPREDNISOLONE 400 MG/5 ML?
METHYLPREDNISOLONE 400 MG/5 ML (NDC 25021082105) is labeled by Sagent Pharmaceuticals, and CMS classifies it as a generic product.
Is METHYLPREDNISOLONE 400 MG/5 ML in shortage?
Yes — NDC 25021082105 is currently listed in FDA's drug shortage database (posted Dec 15, 2021). Reported reason: Shortage of an active ingredient.