Product Information

PROMETHAZINE-CODEINE SOLUTION is a generic product labeled by Cranbury Pharmaceuticals, LLC, priced at $0.0682 per ML under NDC 27808006502. Its NADAC has been published 415 times since Sep 12, 2018.

FDA first approved this application on Jun 29, 2012. Its Orange Book therapeutic-equivalence code is AA.

PROMETHAZINE-CODEINE SOLUTION

Promethazine Hydrochloride and Codeine Phosphate
$0.0682per ML
DEA Schedule CV

Strength

10; 6.25 mg/5mL; mg/5mL

NDC

27808006502

Classification

Generic

Dosage Form

SOLUTION

Route

ORAL

Effective Date

8/19/2026

Approval Type

Generic (ANDA)

FDA Application

ANDA200386

FDA Approved

6/29/2012

TE Code

AA

On Market Since

3/12/2018

Pharmacological Classes

Full Opioid Agonists
Opioid Agonist
Phenothiazine
Phenothiazines

Price Statistics

The NADAC for PROMETHAZINE-CODEINE SOLUTION has been published 415 times since Sep 12, 2018, and over the history we have for it it has risen 266.5%. The table below summarizes its recorded NADAC range and movement.

Current price$0.0682 per ML
All-time high$0.0682 (Aug 19, 2026)
All-time low$0.0186 (Sep 12, 2018)
52-week high$0.0682
52-week low$0.0399
Median price$0.0397
Average price$0.0396
Largest weekly change+39.3% (Sep 23, 2020)
Weeks tracked415
Tracking sinceSep 12, 2018

Price History

1W

+2.3%

1M

+2.3%

3M

+18.3%

6M

+36.2%

1Y

+71.1%

3Y

+90.0%

5Y

+35.2%

All

+266.5%

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Frequently asked questions

What is the NADAC price of PROMETHAZINE-CODEINE SOLUTION?

The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-CODEINE SOLUTION, manufactured by Cranbury Pharmaceuticals, LLC, is $0.0682 per ML (NDC 27808006502), effective Aug 19, 2026.

How has the price of PROMETHAZINE-CODEINE SOLUTION changed over time?

Over the history we have for it, the NADAC for PROMETHAZINE-CODEINE SOLUTION has risen 266.5%. It has been tracked across 415 weekly CMS publications since Sep 12, 2018.

What are the highest and lowest recorded NADAC prices for PROMETHAZINE-CODEINE SOLUTION?

Since Sep 12, 2018, the NADAC for PROMETHAZINE-CODEINE SOLUTION has ranged from a low of $0.0186 (Sep 12, 2018) to a high of $0.0682 (Aug 19, 2026), with a median of $0.0397 per ML.

Are there cheaper alternatives to PROMETHAZINE-CODEINE SOLUTION?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE-CODEINE SOLUTION in a comparable dosage form, but none are currently priced below it.

Who manufactures PROMETHAZINE-CODEINE SOLUTION?

PROMETHAZINE-CODEINE SOLUTION (NDC 27808006502) is labeled by Cranbury Pharmaceuticals, LLC, and CMS classifies it as a generic product.