Product Information
LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB is a generic product labeled by Macleods Pharmaceuticals Limited, priced at $0.0554 per EA under NDC 33342005007. Its NADAC has been published 258 times since Oct 27, 2021.
FDA first approved this application on Aug 9, 2012. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
12.5; 50 mg/1; mg/1
Manufacturer
Macleods Pharmaceuticals LimitedNDC
33342005007
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
HYDROCHLOROTHIAZIDE; LOSARTAN POTASSIUMApproval Type
Generic (ANDA)
FDA Application
ANDA202289FDA Approved
8/9/2012
TE Code
AB
On Market Since
9/10/2012
Pharmacological Classes
Price Statistics
The NADAC for LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB has been published 258 times since Oct 27, 2021, and over the history we have for it it has declined 59.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0554 per EA |
|---|---|
| All-time high | $0.1848 (Apr 13, 2022) |
| All-time low | $0.0554 (Sep 23, 2026) |
| 52-week high | $0.0783 |
| 52-week low | $0.0554 |
| Median price | $0.0898 |
| Average price | $0.0995 |
| Largest weekly change | -22.4% (Nov 20, 2024) |
| Weeks tracked | 258 |
| Tracking since | Oct 27, 2021 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Macleods Pharmaceuticals Limited manufacturer profile
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Drug market
Losartan potassium and Hydrochlorothiazide market comparison
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Therapeutic class
Angiotensin 2 Receptor Blocker class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB, manufactured by Macleods Pharmaceuticals Limited, is $0.0554 per EA (NDC 33342005007), effective Sep 30, 2026.
How has the price of LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB changed over time?
Over the history we have for it, the NADAC for LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB has declined 59.7%. It has been tracked across 258 weekly CMS publications since Oct 27, 2021.
What are the highest and lowest recorded NADAC prices for LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB?
Since Oct 27, 2021, the NADAC for LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB has ranged from a low of $0.0554 (Sep 23, 2026) to a high of $0.1848 (Apr 13, 2022), with a median of $0.0898 per EA.
Are there cheaper alternatives to LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB?
LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB (NDC 33342005007) is labeled by Macleods Pharmaceuticals Limited, and CMS classifies it as a generic product.