This NDC is on FDA's drug shortage list (posted Jun 16, 2022)
Reported reason: Demand increase for the drug
Product Information
METHYLPREDNISOLONE 400 MG/5 ML is a generic product labeled by Endo USA Inc., priced at $13.0533 per ML under NDC 42023024001. Its NADAC has been published 87 times since Sep 18, 2024.
FDA first approved this application on Jan 21, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
80 mg/mL
Manufacturer
Endo USA Inc.NDC
42023024001
Classification
Generic
Dosage Form
INJECTION, SUSPENSION
Route
INTRA-ARTERIAL; INTRALESIONAL; INTRAMUSCULAR; SOFT TISSUE
Effective Date
5/21/2025
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
Generic (ANDA)
FDA Application
ANDA214297FDA Approved
1/21/2022
TE Code
AB
On Market Since
6/30/2022
Pharmacological Classes
Price Statistics
The NADAC for METHYLPREDNISOLONE 400 MG/5 ML has been published 87 times since Sep 18, 2024, and over the history we have for it it has declined 12.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $13.0533 per ML |
|---|---|
| All-time high | $14.9732 (Oct 16, 2024) |
| All-time low | $13.0533 (May 21, 2025) |
| 52-week high | $13.0533 |
| 52-week low | $13.0533 |
| Median price | $13.0533 |
| Average price | $13.4333 |
| Largest weekly change | -5.1% (Oct 23, 2024) |
| Weeks tracked | 87 |
| Tracking since | Sep 18, 2024 |
1W
N/A
1M
N/A
3M
N/A
6M
0.0%
1Y
0.0%
3Y
N/A
5Y
N/A
All
-12.8%
Last surveyed May 13, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHYLPREDNISOLONE 400 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for METHYLPREDNISOLONE 400 MG/5 ML, manufactured by Endo USA Inc., is $13.0533 per ML (NDC 42023024001), effective May 13, 2026.
How has the price of METHYLPREDNISOLONE 400 MG/5 ML changed over time?
Over the history we have for it, the NADAC for METHYLPREDNISOLONE 400 MG/5 ML has declined 12.8%. It has been tracked across 87 weekly CMS publications since Sep 18, 2024.
What are the highest and lowest recorded NADAC prices for METHYLPREDNISOLONE 400 MG/5 ML?
Since Sep 18, 2024, the NADAC for METHYLPREDNISOLONE 400 MG/5 ML has ranged from a low of $13.0533 (May 21, 2025) to a high of $14.9732 (Oct 16, 2024), with a median of $13.0533 per ML.
Are there cheaper alternatives to METHYLPREDNISOLONE 400 MG/5 ML?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as METHYLPREDNISOLONE 400 MG/5 ML in a comparable dosage form, but none are currently priced below it.
Who manufactures METHYLPREDNISOLONE 400 MG/5 ML?
METHYLPREDNISOLONE 400 MG/5 ML (NDC 42023024001) is labeled by Endo USA Inc., and CMS classifies it as a generic product.
Is METHYLPREDNISOLONE 400 MG/5 ML in shortage?
Yes — NDC 42023024001 is currently listed in FDA's drug shortage database (posted Jun 16, 2022). Reported reason: Demand increase for the drug.