Product Information
BUPROPION HCL SR 100 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $0.0687 per EA under NDC 42806041001. Its NADAC has been published 229 times since Apr 6, 2022.
FDA first approved this application on Nov 25, 2003. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
100 mg/1
Manufacturer
Epic Pharma LLCNDC
42806041001
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA075932FDA Approved
11/25/2003
TE Code
AB1
On Market Since
12/15/2021
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL SR 100 MG TABLET has been published 229 times since Apr 6, 2022, and over the history we have for it it has declined 39.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0687 per EA |
|---|---|
| All-time high | $0.1153 (Oct 11, 2023) |
| All-time low | $0.0639 (Oct 22, 2025) |
| 52-week high | $0.0812 |
| 52-week low | $0.0639 |
| Median price | $0.0946 |
| Average price | $0.0914 |
| Largest weekly change | +30.2% (Jun 19, 2024) |
| Weeks tracked | 229 |
| Tracking since | Apr 6, 2022 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BUPROPION HCL SR 100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL SR 100 MG TABLET, manufactured by Epic Pharma LLC, is $0.0687 per EA (NDC 42806041001), effective Aug 19, 2026.
How has the price of BUPROPION HCL SR 100 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL SR 100 MG TABLET has declined 39.0%. It has been tracked across 229 weekly CMS publications since Apr 6, 2022.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL SR 100 MG TABLET?
Since Apr 6, 2022, the NADAC for BUPROPION HCL SR 100 MG TABLET has ranged from a low of $0.0639 (Oct 22, 2025) to a high of $0.1153 (Oct 11, 2023), with a median of $0.0946 per EA.
Are there cheaper alternatives to BUPROPION HCL SR 100 MG TABLET?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL SR 100 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL SR 100 MG TABLET?
BUPROPION HCL SR 100 MG TABLET (NDC 42806041001) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.