Product Information
HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET is a generic product labeled by Rhodes Pharmaceuticals L.P., priced at $0.1361 per EA under NDC 42858020101. Its NADAC has been published 542 times since May 18, 2016.
FDA first approved this application on Apr 12, 2016. Its Orange Book therapeutic-equivalence code is AA.
Strength
325; 5 mg/1; mg/1
Manufacturer
Rhodes Pharmaceuticals L.P.NDC
42858020101
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHEN; HYDROCODONE BITARTRATEApproval Type
Generic (ANDA)
FDA Application
ANDA202991FDA Approved
4/12/2016
TE Code
AA
On Market Since
4/12/2016
Pharmacological Classes
Price Statistics
The NADAC for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET has been published 542 times since May 18, 2016, and over the history we have for it it has held within roughly two percent of its current level. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1361 per EA |
|---|---|
| All-time high | $0.1518 (Jul 10, 2024) |
| All-time low | $0.0764 (Nov 20, 2019) |
| 52-week high | $0.1388 |
| 52-week low | $0.1273 |
| Median price | $0.1083 |
| Average price | $0.1123 |
| Largest weekly change | +33.6% (Jan 22, 2020) |
| Weeks tracked | 542 |
| Tracking since | May 18, 2016 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 22% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Rhodes Pharmaceuticals L.P. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Hydrocodone Bitartrate and Acetaminophen market comparison
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Therapeutic class
Opioid Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET, manufactured by Rhodes Pharmaceuticals L.P., is $0.1361 per EA (NDC 42858020101), effective Sep 30, 2026.
How has the price of HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET changed over time?
Over the history we have for it, the NADAC for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET has held within roughly two percent of its current level. It has been tracked across 542 weekly CMS publications since May 18, 2016.
What are the highest and lowest recorded NADAC prices for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
Since May 18, 2016, the NADAC for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET has ranged from a low of $0.0764 (Nov 20, 2019) to a high of $0.1518 (Jul 10, 2024), with a median of $0.1083 per EA.
Are there cheaper alternatives to HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
Yes. 12 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET, is $0.1066 per EA — about 22% below HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET.
Who manufactures HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET (NDC 42858020101) is labeled by Rhodes Pharmaceuticals L.P., and CMS classifies it as a generic product.