Product Information
HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET is a generic product labeled by AvPAK, priced at $0.1384 per EA under NDC 50268040115. Its NADAC has been published 458 times since Nov 15, 2017.
FDA first approved this application on Aug 25, 2006. Its Orange Book therapeutic-equivalence code is AA.
Strength
325; 5 mg/1; mg/1
Manufacturer
AvPAKNDC
50268040115
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ACETAMINOPHEN; HYDROCODONE BITARTRATEApproval Type
Generic (ANDA)
FDA Application
ANDA040736FDA Approved
8/25/2006
TE Code
AA
On Market Since
9/15/2014
Pharmacological Classes
Price Statistics
The NADAC for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET has been published 458 times since Nov 15, 2017, and over the history we have for it it has risen 24.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1384 per EA |
|---|---|
| All-time high | $0.1518 (Jul 10, 2024) |
| All-time low | $0.0764 (Nov 20, 2019) |
| 52-week high | $0.1388 |
| 52-week low | $0.1273 |
| Median price | $0.1058 |
| Average price | $0.1095 |
| Largest weekly change | +33.6% (Jan 22, 2020) |
| Weeks tracked | 458 |
| Tracking since | Nov 15, 2017 |
Generic Alternatives
The matcher finds 11 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 23% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET, manufactured by AvPAK, is $0.1384 per EA (NDC 50268040115), effective Aug 19, 2026.
How has the price of HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET changed over time?
Over the history we have for it, the NADAC for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET has risen 24.0%. It has been tracked across 458 weekly CMS publications since Nov 15, 2017.
What are the highest and lowest recorded NADAC prices for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
Since Nov 15, 2017, the NADAC for HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET has ranged from a low of $0.0764 (Nov 20, 2019) to a high of $0.1518 (Jul 10, 2024), with a median of $0.1058 per EA.
Are there cheaper alternatives to HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
Yes. 11 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET, is $0.1066 per EA — about 23% below HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET.
Who manufactures HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET?
HYDROCODONE-ACETAMINOPHEN 5-325 MG TABLET (NDC 50268040115) is labeled by AvPAK, and CMS classifies it as a generic product.