Product Information
CYANOCOBALAMIN 500 MCG SPRAY is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $95.9084 per EA under NDC 45802049184. Its NADAC has been published 133 times since Mar 20, 2024.
FDA first approved this application on Sep 9, 2020. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the cyanocobalamin market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
500 ug/1
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802049184
Classification
Generic
Dosage Form
SPRAY
Route
NASAL
Effective Date
9/23/2026
Active Ingredients
CYANOCOBALAMINApproval Type
Generic (ANDA)
FDA Application
ANDA212458FDA Approved
9/9/2020
TE Code
AB
On Market Since
12/28/2023
Pharmacological Classes
Price Statistics
The NADAC for CYANOCOBALAMIN 500 MCG SPRAY has been published 133 times since Mar 20, 2024, and over the history we have for it it has declined 28.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $95.9084 per EA |
|---|---|
| All-time high | $134.4279 (Apr 10, 2024) |
| All-time low | $94.0201 (Aug 20, 2025) |
| 52-week high | $124.1779 |
| 52-week low | $94.0867 |
| Median price | $104.9987 |
| Average price | $107.0015 |
| Largest weekly change | -14.0% (Apr 17, 2024) |
| Weeks tracked | 133 |
| Tracking since | Mar 20, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
cyanocobalamin market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Vitamin B12 class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CYANOCOBALAMIN 500 MCG SPRAY?
The current National Average Drug Acquisition Cost (NADAC) for CYANOCOBALAMIN 500 MCG SPRAY, manufactured by Padagis Israel Pharmaceuticals Ltd, is $95.9084 per EA (NDC 45802049184), effective Sep 30, 2026.
How has the price of CYANOCOBALAMIN 500 MCG SPRAY changed over time?
Over the history we have for it, the NADAC for CYANOCOBALAMIN 500 MCG SPRAY has declined 28.7%. It has been tracked across 133 weekly CMS publications since Mar 20, 2024.
What are the highest and lowest recorded NADAC prices for CYANOCOBALAMIN 500 MCG SPRAY?
Since Mar 20, 2024, the NADAC for CYANOCOBALAMIN 500 MCG SPRAY has ranged from a low of $94.0201 (Aug 20, 2025) to a high of $134.4279 (Apr 10, 2024), with a median of $104.9987 per EA.
Are there cheaper alternatives to CYANOCOBALAMIN 500 MCG SPRAY?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as CYANOCOBALAMIN 500 MCG SPRAY in a comparable dosage form, but none are currently priced below it.
Who manufactures CYANOCOBALAMIN 500 MCG SPRAY?
CYANOCOBALAMIN 500 MCG SPRAY (NDC 45802049184) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.