Product Information

CYANOCOBALAMIN 500 MCG SPRAY is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $98.8340 per EA under NDC 45802049184. Its NADAC has been published 127 times since Mar 20, 2024.

FDA first approved this application on Sep 9, 2020. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

The High Outlier badge above means this manufacturer's average price in the cyanocobalamin market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.

CYANOCOBALAMIN 500 MCG SPRAY

cyanocobalamin
$98.8340per EA
High Outlier

Strength

500 ug/1

NDC

45802049184

Classification

Generic

Dosage Form

SPRAY

Route

NASAL

Effective Date

8/19/2026

Active Ingredients

CYANOCOBALAMIN

Approval Type

Generic (ANDA)

FDA Application

ANDA212458

FDA Approved

9/9/2020

TE Code

AB

On Market Since

12/28/2023

Pharmacological Classes

Vitamin B 12
Vitamin B12

Price Statistics

The NADAC for CYANOCOBALAMIN 500 MCG SPRAY has been published 127 times since Mar 20, 2024, and over the history we have for it it has declined 26.5%. The table below summarizes its recorded NADAC range and movement.

Current price$98.8340 per EA
All-time high$134.4279 (Apr 10, 2024)
All-time low$94.0201 (Aug 20, 2025)
52-week high$124.1779
52-week low$94.0201
Median price$105.1218
Average price$107.4334
Largest weekly change-14.0% (Apr 17, 2024)
Weeks tracked127
Tracking sinceMar 20, 2024

Price History

1W

-0.5%

1M

-0.5%

3M

-10.4%

6M

-19.7%

1Y

+5.1%

3Y

N/A

5Y

N/A

All

-26.5%

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Frequently asked questions

What is the NADAC price of CYANOCOBALAMIN 500 MCG SPRAY?

The current National Average Drug Acquisition Cost (NADAC) for CYANOCOBALAMIN 500 MCG SPRAY, manufactured by Padagis Israel Pharmaceuticals Ltd, is $98.8340 per EA (NDC 45802049184), effective Aug 19, 2026.

How has the price of CYANOCOBALAMIN 500 MCG SPRAY changed over time?

Over the history we have for it, the NADAC for CYANOCOBALAMIN 500 MCG SPRAY has declined 26.5%. It has been tracked across 127 weekly CMS publications since Mar 20, 2024.

What are the highest and lowest recorded NADAC prices for CYANOCOBALAMIN 500 MCG SPRAY?

Since Mar 20, 2024, the NADAC for CYANOCOBALAMIN 500 MCG SPRAY has ranged from a low of $94.0201 (Aug 20, 2025) to a high of $134.4279 (Apr 10, 2024), with a median of $105.1218 per EA.

Are there cheaper alternatives to CYANOCOBALAMIN 500 MCG SPRAY?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as CYANOCOBALAMIN 500 MCG SPRAY in a comparable dosage form, but none are currently priced below it.

Who manufactures CYANOCOBALAMIN 500 MCG SPRAY?

CYANOCOBALAMIN 500 MCG SPRAY (NDC 45802049184) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.