Product Information
NASCOBAL 500 MCG NASAL SPRAY is a brand product labeled by Endo USA Inc., priced at $171.7392 per EA under NDC 49884027082. Its NADAC has been published 583 times since May 20, 2015.
FDA first approved this application on Jan 31, 2005.
The High Outlier badge above means this manufacturer's average price in the cyanocobalamin market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
500 ug/1
Manufacturer
Endo USA Inc.NDC
49884027082
Classification
Brand
Dosage Form
SPRAY
Route
NASAL
Effective Date
7/23/2025
Active Ingredients
CYANOCOBALAMINApproval Type
New Drug (NDA)
FDA Application
NDA021642FDA Approved
1/31/2005
On Market Since
8/13/2009
Pharmacological Classes
Price Statistics
The NADAC for NASCOBAL 500 MCG NASAL SPRAY has been published 583 times since May 20, 2015, and over the history we have for it it has risen 80.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $171.7392 per EA |
|---|---|
| All-time high | $171.7392 (Jul 15, 2026) |
| All-time low | $95.3558 (Jun 17, 2015) |
| 52-week high | $171.7392 |
| 52-week low | $171.7392 |
| Median price | $147.8297 |
| Average price | $145.7601 |
| Largest weekly change | +9.9% (Jul 12, 2017) |
| Weeks tracked | 583 |
| Tracking since | May 20, 2015 |
1W
N/A
1M
N/A
3M
0.0%
6M
0.0%
1Y
0.0%
3Y
+1.1%
5Y
+11.3%
All
+80.0%
Last surveyed Jul 15, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 42% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of NASCOBAL 500 MCG NASAL SPRAY?
The current National Average Drug Acquisition Cost (NADAC) for NASCOBAL 500 MCG NASAL SPRAY, manufactured by Endo USA Inc., is $171.7392 per EA (NDC 49884027082), effective Jul 15, 2026.
How has the price of NASCOBAL 500 MCG NASAL SPRAY changed over time?
Over the history we have for it, the NADAC for NASCOBAL 500 MCG NASAL SPRAY has risen 80.0%. It has been tracked across 583 weekly CMS publications since May 20, 2015.
What are the highest and lowest recorded NADAC prices for NASCOBAL 500 MCG NASAL SPRAY?
Since May 20, 2015, the NADAC for NASCOBAL 500 MCG NASAL SPRAY has ranged from a low of $95.3558 (Jun 17, 2015) to a high of $171.7392 (Jul 15, 2026), with a median of $147.8297 per EA.
Are there cheaper alternatives to NASCOBAL 500 MCG NASAL SPRAY?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CYANOCOBALAMIN 500 MCG SPRAY, is $98.8340 per EA — about 42% below NASCOBAL 500 MCG NASAL SPRAY.
Who manufactures NASCOBAL 500 MCG NASAL SPRAY?
NASCOBAL 500 MCG NASAL SPRAY (NDC 49884027082) is labeled by Endo USA Inc., and CMS classifies it as a brand product.