Product Information
AMITRIPTYLINE HCL 25 MG TAB is a generic product labeled by NorthStar Rx LLC, priced at $0.0512 per EA under NDC 16714025801. Its NADAC has been published 203 times since Oct 5, 2022.
FDA first approved this application on Oct 6, 2017. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
NorthStar Rx LLCNDC
16714025801
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
AMITRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA210086FDA Approved
10/6/2017
TE Code
AB
On Market Since
8/25/2021
Pharmacological Classes
Price Statistics
The NADAC for AMITRIPTYLINE HCL 25 MG TAB has been published 203 times since Oct 5, 2022, and over the history we have for it it has declined 2.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0512 per EA |
|---|---|
| All-time high | $0.0703 (Apr 10, 2024) |
| All-time low | $0.0411 (Nov 20, 2024) |
| 52-week high | $0.0566 |
| 52-week low | $0.0509 |
| Median price | $0.0558 |
| Average price | $0.0568 |
| Largest weekly change | -27.3% (Nov 20, 2024) |
| Weeks tracked | 203 |
| Tracking since | Oct 5, 2022 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of AMITRIPTYLINE HCL 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for AMITRIPTYLINE HCL 25 MG TAB, manufactured by NorthStar Rx LLC, is $0.0512 per EA (NDC 16714025801), effective Aug 19, 2026.
How has the price of AMITRIPTYLINE HCL 25 MG TAB changed over time?
Over the history we have for it, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has declined 2.1%. It has been tracked across 203 weekly CMS publications since Oct 5, 2022.
What are the highest and lowest recorded NADAC prices for AMITRIPTYLINE HCL 25 MG TAB?
Since Oct 5, 2022, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has ranged from a low of $0.0411 (Nov 20, 2024) to a high of $0.0703 (Apr 10, 2024), with a median of $0.0558 per EA.
Are there cheaper alternatives to AMITRIPTYLINE HCL 25 MG TAB?
12 manufacturers publish a NADAC-priced product with the same active ingredient and strength as AMITRIPTYLINE HCL 25 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures AMITRIPTYLINE HCL 25 MG TAB?
AMITRIPTYLINE HCL 25 MG TAB (NDC 16714025801) is labeled by NorthStar Rx LLC, and CMS classifies it as a generic product.