Product Information
CHLORTHALIDONE 25 MG TABLET is a generic product labeled by AvPAK, priced at $0.0743 per EA under NDC 50268016715. Its NADAC has been published 341 times since Mar 25, 2020.
FDA first approved this application on Oct 12, 2018. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The Low Outlier badge above means this manufacturer's average price in the CHLORTHALIDONE market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25 mg/1
Manufacturer
AvPAKNDC
50268016715
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
CHLORTHALIDONEApproval Type
Generic (ANDA)
FDA Application
ANDA210742FDA Approved
10/12/2018
TE Code
AB
On Market Since
11/12/2019
Pharmacological Classes
Price Statistics
The NADAC for CHLORTHALIDONE 25 MG TABLET has been published 341 times since Mar 25, 2020, and over the history we have for it it has declined 79.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0743 per EA |
|---|---|
| All-time high | $0.3562 (Apr 15, 2020) |
| All-time low | $0.0703 (Jul 17, 2024) |
| 52-week high | $0.0901 |
| 52-week low | $0.0743 |
| Median price | $0.1021 |
| Average price | $0.1394 |
| Largest weekly change | +30.9% (Aug 21, 2024) |
| Weeks tracked | 341 |
| Tracking since | Mar 25, 2020 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
AvPAK manufacturer profile
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Drug market
CHLORTHALIDONE market comparison
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Therapeutic class
Thiazide-like Diuretic class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CHLORTHALIDONE 25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for CHLORTHALIDONE 25 MG TABLET, manufactured by AvPAK, is $0.0743 per EA (NDC 50268016715), effective Sep 30, 2026.
How has the price of CHLORTHALIDONE 25 MG TABLET changed over time?
Over the history we have for it, the NADAC for CHLORTHALIDONE 25 MG TABLET has declined 79.1%. It has been tracked across 341 weekly CMS publications since Mar 25, 2020.
What are the highest and lowest recorded NADAC prices for CHLORTHALIDONE 25 MG TABLET?
Since Mar 25, 2020, the NADAC for CHLORTHALIDONE 25 MG TABLET has ranged from a low of $0.0703 (Jul 17, 2024) to a high of $0.3562 (Apr 15, 2020), with a median of $0.1021 per EA.
Are there cheaper alternatives to CHLORTHALIDONE 25 MG TABLET?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as CHLORTHALIDONE 25 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures CHLORTHALIDONE 25 MG TABLET?
CHLORTHALIDONE 25 MG TABLET (NDC 50268016715) is labeled by AvPAK, and CMS classifies it as a generic product.