Product Information
OXYCODONE-ACETAMINOPHEN 5-325 MG TAB is a generic product labeled by AvPAK, priced at $0.1171 per EA under NDC 50268064415. Its NADAC has been published 408 times since Dec 12, 2018.
FDA first approved this application on Nov 27, 2007. Its Orange Book therapeutic-equivalence code is AA.
Strength
325; 5 mg/1; mg/1
Manufacturer
AvPAKNDC
50268064415
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHEN; OXYCODONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040777FDA Approved
11/27/2007
TE Code
AA
On Market Since
7/9/2018
Pharmacological Classes
Price Statistics
The NADAC for OXYCODONE-ACETAMINOPHEN 5-325 MG TAB has been published 408 times since Dec 12, 2018, and over the history we have for it it has risen 33.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1171 per EA |
|---|---|
| All-time high | $0.1339 (Apr 16, 2025) |
| All-time low | $0.0776 (May 20, 2020) |
| 52-week high | $0.1228 |
| 52-week low | $0.1171 |
| Median price | $0.0973 |
| Average price | $0.1012 |
| Largest weekly change | +13.9% (Feb 22, 2023) |
| Weeks tracked | 408 |
| Tracking since | Dec 12, 2018 |
Generic Alternatives
The matcher finds 10 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 26% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
AvPAK manufacturer profile
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Drug market
Oxycodone and Acetaminophen market comparison
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Therapeutic class
Opioid Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of OXYCODONE-ACETAMINOPHEN 5-325 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for OXYCODONE-ACETAMINOPHEN 5-325 MG TAB, manufactured by AvPAK, is $0.1171 per EA (NDC 50268064415), effective Sep 30, 2026.
How has the price of OXYCODONE-ACETAMINOPHEN 5-325 MG TAB changed over time?
Over the history we have for it, the NADAC for OXYCODONE-ACETAMINOPHEN 5-325 MG TAB has risen 33.2%. It has been tracked across 408 weekly CMS publications since Dec 12, 2018.
What are the highest and lowest recorded NADAC prices for OXYCODONE-ACETAMINOPHEN 5-325 MG TAB?
Since Dec 12, 2018, the NADAC for OXYCODONE-ACETAMINOPHEN 5-325 MG TAB has ranged from a low of $0.0776 (May 20, 2020) to a high of $0.1339 (Apr 16, 2025), with a median of $0.0973 per EA.
Are there cheaper alternatives to OXYCODONE-ACETAMINOPHEN 5-325 MG TAB?
Yes. 10 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, OXYCODONE-ACETAMINOPHEN 5-325 MG TABLET, is $0.0864 per EA — about 26% below OXYCODONE-ACETAMINOPHEN 5-325 MG TAB.
Who manufactures OXYCODONE-ACETAMINOPHEN 5-325 MG TAB?
OXYCODONE-ACETAMINOPHEN 5-325 MG TAB (NDC 50268064415) is labeled by AvPAK, and CMS classifies it as a generic product.