Product Information
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB is a generic product labeled by Sun Pharmaceutical Industries Inc., priced at $0.4833 per EA under NDC 53489014405. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Jul 2, 1987. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The Low Outlier badge above means this manufacturer's average price in the Spironolactone and Hydrochlorothiazide market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25; 25 mg/1; mg/1
Manufacturer
Sun Pharmaceutical Industries Inc.NDC
53489014405
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
HYDROCHLOROTHIAZIDE; SPIRONOLACTONEApproval Type
Generic (ANDA)
FDA Application
ANDA089534FDA Approved
7/2/1987
TE Code
AB
On Market Since
7/2/1987
Pharmacological Classes
Price Statistics
The NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 28.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4833 per EA |
|---|---|
| All-time high | $1.1475 (Dec 10, 2014) |
| All-time low | $0.3906 (Nov 20, 2024) |
| 52-week high | $0.5620 |
| 52-week low | $0.4833 |
| Median price | $0.7262 |
| Average price | $0.7530 |
| Largest weekly change | +37.7% (Aug 21, 2024) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 2% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Sun Pharmaceutical Industries Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Spironolactone and Hydrochlorothiazide market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Aldosterone Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
The current National Average Drug Acquisition Cost (NADAC) for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB, manufactured by Sun Pharmaceutical Industries Inc., is $0.4833 per EA (NDC 53489014405), effective Sep 30, 2026.
How has the price of SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB changed over time?
Over the history we have for it, the NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has declined 28.3%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
Since Nov 28, 2013, the NADAC for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB has ranged from a low of $0.3906 (Nov 20, 2024) to a high of $1.1475 (Dec 10, 2014), with a median of $0.7262 per EA.
Are there cheaper alternatives to SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB, is $0.4757 per EA — about 2% below SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB.
Who manufactures SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB?
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB (NDC 53489014405) is labeled by Sun Pharmaceutical Industries Inc., and CMS classifies it as a generic product.