Product Information
M-DRYL 12.5 MG/5 ML SOLUTION is a generic product labeled by Method Pharmaceuticals LLC, priced at $0.0192 per ML under NDC 58657052804. Its NADAC has been published 129 times since Apr 17, 2024.
Strength
12.5 mg/5mL
Manufacturer
Method Pharmaceuticals LLCNDC
58657052804
Classification
Generic
Dosage Form
LIQUID
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M012On Market Since
8/1/2019
Pharmacological Classes
Price Statistics
The NADAC for M-DRYL 12.5 MG/5 ML SOLUTION has been published 129 times since Apr 17, 2024, and over the history we have for it it has declined 31.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0192 per ML |
|---|---|
| All-time high | $0.0282 (Jul 10, 2024) |
| All-time low | $0.0164 (Feb 12, 2025) |
| 52-week high | $0.0199 |
| 52-week low | $0.0173 |
| Median price | $0.0194 |
| Average price | $0.0214 |
| Largest weekly change | -40.1% (Feb 12, 2025) |
| Weeks tracked | 129 |
| Tracking since | Apr 17, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 9% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Method Pharmaceuticals LLC manufacturer profile
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Drug market
DIPHENHYDRAMINE HYDROCHLORIDE market comparison
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Therapeutic class
Histamine-1 Receptor Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of M-DRYL 12.5 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for M-DRYL 12.5 MG/5 ML SOLUTION, manufactured by Method Pharmaceuticals LLC, is $0.0192 per ML (NDC 58657052804), effective Sep 30, 2026.
How has the price of M-DRYL 12.5 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for M-DRYL 12.5 MG/5 ML SOLUTION has declined 31.8%. It has been tracked across 129 weekly CMS publications since Apr 17, 2024.
What are the highest and lowest recorded NADAC prices for M-DRYL 12.5 MG/5 ML SOLUTION?
Since Apr 17, 2024, the NADAC for M-DRYL 12.5 MG/5 ML SOLUTION has ranged from a low of $0.0164 (Feb 12, 2025) to a high of $0.0282 (Jul 10, 2024), with a median of $0.0194 per ML.
Are there cheaper alternatives to M-DRYL 12.5 MG/5 ML SOLUTION?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, M-DRYL 12.5 MG/5 ML SOLUTION, is $0.0174 per ML — about 9% below M-DRYL 12.5 MG/5 ML SOLUTION.
Who manufactures M-DRYL 12.5 MG/5 ML SOLUTION?
M-DRYL 12.5 MG/5 ML SOLUTION (NDC 58657052804) is labeled by Method Pharmaceuticals LLC, and CMS classifies it as a generic product.