Product Information
HYDROCORTISONE 2.5% CREAM is a generic product labeled by ANI Pharmaceuticals, Inc., priced at $0.2350 per GM under NDC 62559043130. Its NADAC has been published 534 times since Jun 15, 2016.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AT.
Strength
25 mg/g
Manufacturer
ANI Pharmaceuticals, Inc.NDC
62559043130
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
HYDROCORTISONEApproval Type
Generic (ANDA)
FDA Application
ANDA080706FDA Approved
Before 1982
TE Code
AT
On Market Since
4/1/2016
Pharmacological Classes
Price Statistics
The NADAC for HYDROCORTISONE 2.5% CREAM has been published 534 times since Jun 15, 2016, and over the history we have for it it has declined 87.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2350 per GM |
|---|---|
| All-time high | $1.8561 (Jun 15, 2016) |
| All-time low | $0.2040 (Nov 20, 2024) |
| 52-week high | $0.2641 |
| 52-week low | $0.2345 |
| Median price | $0.3620 |
| Average price | $0.4990 |
| Largest weekly change | -23.1% (Nov 20, 2024) |
| Weeks tracked | 534 |
| Tracking since | Jun 15, 2016 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 66% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
ANI Pharmaceuticals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Hydrocortisone market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of HYDROCORTISONE 2.5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for HYDROCORTISONE 2.5% CREAM, manufactured by ANI Pharmaceuticals, Inc., is $0.2350 per GM (NDC 62559043130), effective Sep 30, 2026.
How has the price of HYDROCORTISONE 2.5% CREAM changed over time?
Over the history we have for it, the NADAC for HYDROCORTISONE 2.5% CREAM has declined 87.3%. It has been tracked across 534 weekly CMS publications since Jun 15, 2016.
What are the highest and lowest recorded NADAC prices for HYDROCORTISONE 2.5% CREAM?
Since Jun 15, 2016, the NADAC for HYDROCORTISONE 2.5% CREAM has ranged from a low of $0.2040 (Nov 20, 2024) to a high of $1.8561 (Jun 15, 2016), with a median of $0.3620 per GM.
Are there cheaper alternatives to HYDROCORTISONE 2.5% CREAM?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROCORTISONE 2.5% CREAM, is $0.0799 per GM — about 66% below HYDROCORTISONE 2.5% CREAM.
Who manufactures HYDROCORTISONE 2.5% CREAM?
HYDROCORTISONE 2.5% CREAM (NDC 62559043130) is labeled by ANI Pharmaceuticals, Inc., and CMS classifies it as a generic product.