Historical record - last NADAC effective date: 9/18/2024
Product Information
EPHEDRINE SULFATE 50 MG/ML VL is a generic product labeled by Fresenius Kabi USA, LLC, priced at $5.6366 per ML under NDC 65219025701. Its NADAC has been published 61 times since Jul 17, 2024.
FDA first approved this application on Aug 4, 2020. Its Orange Book therapeutic-equivalence code is AP.
Strength
50 mg/mL
Manufacturer
Fresenius Kabi USA, LLCNDC
65219025701
Classification
Generic
Dosage Form
INJECTION
Route
INTRAVENOUS
Effective Date
9/18/2024
Active Ingredients
EPHEDRINE SULFATEApproval Type
Generic (ANDA)
FDA Application
ANDA209646FDA Approved
8/4/2020
TE Code
AP
On Market Since
10/31/2020
Pharmacological Classes
Price Statistics
The NADAC for EPHEDRINE SULFATE 50 MG/ML VL has been published 61 times since Jul 17, 2024, and over the history we have for it it has risen 2.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $5.6366 per ML |
|---|---|
| All-time high | $5.6366 (Sep 10, 2025) |
| All-time low | $5.4758 (Jul 17, 2024) |
| Median price | $5.6366 |
| Average price | $5.6235 |
| Largest weekly change | +2.9% (Aug 21, 2024) |
| Weeks tracked | 61 |
| Tracking since | Jul 17, 2024 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
N/A
3Y
N/A
5Y
N/A
All
+2.9%
Last surveyed Sep 10, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 3% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Fresenius Kabi USA, LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Ephedrine Sulfate market comparison
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Therapeutic class
Norepinephrine Releasing Agent class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of EPHEDRINE SULFATE 50 MG/ML VL?
The current National Average Drug Acquisition Cost (NADAC) for EPHEDRINE SULFATE 50 MG/ML VL, manufactured by Fresenius Kabi USA, LLC, is $5.6366 per ML (NDC 65219025701), effective Sep 10, 2025.
How has the price of EPHEDRINE SULFATE 50 MG/ML VL changed over time?
Over the history we have for it, the NADAC for EPHEDRINE SULFATE 50 MG/ML VL has risen 2.9%. It has been tracked across 61 weekly CMS publications since Jul 17, 2024.
What are the highest and lowest recorded NADAC prices for EPHEDRINE SULFATE 50 MG/ML VL?
Since Jul 17, 2024, the NADAC for EPHEDRINE SULFATE 50 MG/ML VL has ranged from a low of $5.4758 (Jul 17, 2024) to a high of $5.6366 (Sep 10, 2025), with a median of $5.6366 per ML.
Are there cheaper alternatives to EPHEDRINE SULFATE 50 MG/ML VL?
Yes. 7 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, EPHEDRINE SULFATE 50 MG/ML VL, is $5.4758 per ML — about 3% below EPHEDRINE SULFATE 50 MG/ML VL.
Who manufactures EPHEDRINE SULFATE 50 MG/ML VL?
EPHEDRINE SULFATE 50 MG/ML VL (NDC 65219025701) is labeled by Fresenius Kabi USA, LLC, and CMS classifies it as a generic product.