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Product Information

DIPHENHYDRAMINE 500 MG/10 ML VL is a generic product labeled by Mylan Institutional LLC, priced at $0.7900 per ML under NDC 67457012410. Its NADAC has been published 87 times since Aug 19, 2020.

FDA first approved this application on Jul 12, 2005. Its Orange Book therapeutic-equivalence code is AP.

DIPHENHYDRAMINE 500 MG/10 ML VL

diphenhydramine hydrochloride
$0.7900per ML
Discontinued

Strength

50 mg/mL

NDC

67457012410

Classification

Generic

Dosage Form

INJECTION, SOLUTION

Route

INTRAMUSCULAR; INTRAVENOUS

Effective Date

3/19/2025

Approval Type

Generic (ANDA)

FDA Application

ANDA040498

FDA Approved

7/12/2005

TE Code

AP

On Market Since

5/9/2013

Pharmacological Classes

Histamine H1 Receptor Antagonists
Histamine-1 Receptor Antagonist

Price Statistics

The NADAC for DIPHENHYDRAMINE 500 MG/10 ML VL has been published 87 times since Aug 19, 2020, and over the history we have for it it has risen 599.4%. The table below summarizes its recorded NADAC range and movement.

Current price$0.7900 per ML
All-time high$0.7900 (Feb 25, 2026)
All-time low$0.1129 (Aug 19, 2020)
52-week high$0.7900
52-week low$0.7900
Median price$0.7900
Average price$0.7689
Largest weekly change+583.0% (Jul 17, 2024)
Weeks tracked87
Tracking sinceAug 19, 2020

Price History

1W

N/A

1M

N/A

3M

N/A

6M

0.0%

1Y

0.0%

3Y

+599.4%

5Y

+599.4%

All

+599.4%

Last surveyed Feb 25, 2026 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

1 alternative • Same active ingredient

DIPHENHYDRAMINE 50 MG/ML VIAL
Generic
00641037625•Hikma Pharmaceuticals USA Inc.
$0.9336
+18% more

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$0.0136
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Generic
83324001506•Chain Drug Marketing Association
$0.0136
per ML
CHILD'S ALLERGY 12.5 MG/5 ML
Generic
36800037934•Topco Associates LLC
$0.0143
per ML
CHILD'S ALLERGY 12.5 MG/5 ML
Generic
36800037926•Topco Associates LLC
$0.0145
per ML
QC CHILD ALLERGY 12.5 MG/5 ML
Generic
63868037004•Chain Drug Marketing Association
$0.0155
per ML
QC CHILD ALLERGY 12.5 MG/5 ML
Generic
63868082354•Chain Drug Marketing Association
$0.0155
per ML

Frequently asked questions

What is the NADAC price of DIPHENHYDRAMINE 500 MG/10 ML VL?

The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 500 MG/10 ML VL, manufactured by Mylan Institutional LLC, is $0.7900 per ML (NDC 67457012410), effective Feb 25, 2026.

How has the price of DIPHENHYDRAMINE 500 MG/10 ML VL changed over time?

Over the history we have for it, the NADAC for DIPHENHYDRAMINE 500 MG/10 ML VL has risen 599.4%. It has been tracked across 87 weekly CMS publications since Aug 19, 2020.

What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 500 MG/10 ML VL?

Since Aug 19, 2020, the NADAC for DIPHENHYDRAMINE 500 MG/10 ML VL has ranged from a low of $0.1129 (Aug 19, 2020) to a high of $0.7900 (Feb 25, 2026), with a median of $0.7900 per ML.

Are there cheaper alternatives to DIPHENHYDRAMINE 500 MG/10 ML VL?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as DIPHENHYDRAMINE 500 MG/10 ML VL in a comparable dosage form, but none are currently priced below it.

Who manufactures DIPHENHYDRAMINE 500 MG/10 ML VL?

DIPHENHYDRAMINE 500 MG/10 ML VL (NDC 67457012410) is labeled by Mylan Institutional LLC, and CMS classifies it as a generic product.