Product Information
GLIPIZIDE-METFORMIN 2.5-500 MG is a generic product labeled by Zydus Pharmaceuticals (USA) Inc., priced at $0.2478 per EA under NDC 68382018501. Its NADAC has been published 518 times since Sep 21, 2016.
FDA first approved this application on Jan 31, 2011. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2.5; 500 mg/1; mg/1
Manufacturer
Zydus Pharmaceuticals (USA) Inc.NDC
68382018501
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
GLIPIZIDE; METFORMIN HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA078905FDA Approved
1/31/2011
TE Code
AB
On Market Since
5/5/2016
Pharmacological Classes
Price Statistics
The NADAC for GLIPIZIDE-METFORMIN 2.5-500 MG has been published 518 times since Sep 21, 2016, and over the history we have for it it has declined 50.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2478 per EA |
|---|---|
| All-time high | $0.5867 (Nov 16, 2016) |
| All-time low | $0.1992 (Jun 23, 2021) |
| 52-week high | $0.3088 |
| 52-week low | $0.2223 |
| Median price | $0.2773 |
| Average price | $0.3040 |
| Largest weekly change | +43.5% (Sep 23, 2020) |
| Weeks tracked | 518 |
| Tracking since | Sep 21, 2016 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of GLIPIZIDE-METFORMIN 2.5-500 MG?
The current National Average Drug Acquisition Cost (NADAC) for GLIPIZIDE-METFORMIN 2.5-500 MG, manufactured by Zydus Pharmaceuticals (USA) Inc., is $0.2478 per EA (NDC 68382018501), effective Aug 19, 2026.
How has the price of GLIPIZIDE-METFORMIN 2.5-500 MG changed over time?
Over the history we have for it, the NADAC for GLIPIZIDE-METFORMIN 2.5-500 MG has declined 50.5%. It has been tracked across 518 weekly CMS publications since Sep 21, 2016.
What are the highest and lowest recorded NADAC prices for GLIPIZIDE-METFORMIN 2.5-500 MG?
Since Sep 21, 2016, the NADAC for GLIPIZIDE-METFORMIN 2.5-500 MG has ranged from a low of $0.1992 (Jun 23, 2021) to a high of $0.5867 (Nov 16, 2016), with a median of $0.2773 per EA.
Are there cheaper alternatives to GLIPIZIDE-METFORMIN 2.5-500 MG?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as GLIPIZIDE-METFORMIN 2.5-500 MG in a comparable dosage form, but none are currently priced below it.
Who manufactures GLIPIZIDE-METFORMIN 2.5-500 MG?
GLIPIZIDE-METFORMIN 2.5-500 MG (NDC 68382018501) is labeled by Zydus Pharmaceuticals (USA) Inc., and CMS classifies it as a generic product.