Product Information
DIFLUPREDNATE 0.05% EYE DROP is a generic product labeled by Leading Pharma, LLC, priced at $8.9184 per ML under NDC 69315032905. Its NADAC has been published 64 times since Jun 4, 2025.
FDA first approved this application on Dec 13, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/mL
Manufacturer
Leading Pharma, LLCNDC
69315032905
Classification
Generic
Dosage Form
EMULSION
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
DIFLUPREDNATEApproval Type
Generic (ANDA)
FDA Application
ANDA219441FDA Approved
12/13/2024
TE Code
AB
On Market Since
2/18/2025
Price Statistics
The NADAC for DIFLUPREDNATE 0.05% EYE DROP has been published 64 times since Jun 4, 2025, and over the history we have for it it has declined 29.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.9184 per ML |
|---|---|
| All-time high | $12.5868 (Jun 11, 2025) |
| All-time low | $7.0479 (Jun 17, 2026) |
| 52-week high | $11.3753 |
| 52-week low | $7.0479 |
| Median price | $10.0459 |
| Average price | $9.8106 |
| Largest weekly change | +20.4% (Aug 19, 2026) |
| Weeks tracked | 64 |
| Tracking since | Jun 4, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DIFLUPREDNATE 0.05% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for DIFLUPREDNATE 0.05% EYE DROP, manufactured by Leading Pharma, LLC, is $8.9184 per ML (NDC 69315032905), effective Aug 19, 2026.
How has the price of DIFLUPREDNATE 0.05% EYE DROP changed over time?
Over the history we have for it, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has declined 29.1%. It has been tracked across 64 weekly CMS publications since Jun 4, 2025.
What are the highest and lowest recorded NADAC prices for DIFLUPREDNATE 0.05% EYE DROP?
Since Jun 4, 2025, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has ranged from a low of $7.0479 (Jun 17, 2026) to a high of $12.5868 (Jun 11, 2025), with a median of $10.0459 per ML.
Are there cheaper alternatives to DIFLUPREDNATE 0.05% EYE DROP?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as DIFLUPREDNATE 0.05% EYE DROP in a comparable dosage form, but none are currently priced below it.
Who manufactures DIFLUPREDNATE 0.05% EYE DROP?
DIFLUPREDNATE 0.05% EYE DROP (NDC 69315032905) is labeled by Leading Pharma, LLC, and CMS classifies it as a generic product.