Difluprednate
6 NDCs across 6 manufacturers|5 Generic,1 Brand
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The brand product was first FDA-approved on Jun 23, 2008, and the first generic was approved Aug 9, 2021. FDA's Orange Book lists 8 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $15 million on Difluprednate across 134,000 claims for 62,000 beneficiaries.
Difluprednate is available as 6 NDCs from 6 manufacturers (5 generic, 1 brand), with NADAC prices from $9.69 to $42.25 per ML — the most expensive product costs about 4.4× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
6
5G / 1B
Manufacturers
6
competing in market
Price Spread
$9.69 – $42.25
per ML
7d Activity
avg +8.6% WoW · of 6 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Sandoz Inc. manufacturer profile
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Trend hub
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
6 manufacturers producing DIFLUPREDNATE(1 pricing outlier)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
DUREZOL 0.05% EYE DROPS | $42.2491 per ML | — |
DIFLUPREDNATE 0.05% EYE DROP | $9.7858 per ML | — |
DIFLUPREDNATE 0.05% EYE DROP | $9.6866 per ML | +8.61% |
DIFLUPREDNATE 0.05% EYE DROP | $9.6866 per ML | +8.61% |
DIFLUPREDNATE 0.05% EYE DROP | $9.6866 per ML | +8.61% |
DIFLUPREDNATE 0.05% EYE DROP | $9.6866 per ML | +8.61% |
Frequently Asked Questions
When did Difluprednate become available as a generic?
FDA approved the first generic Difluprednate (ANDA) on Aug 9, 2021. The Orange Book currently lists 8 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Difluprednate?
In 2024, Medicare Part D spent $15 million on Difluprednate across 134,000 claims for 62,000 beneficiaries.
How many Difluprednate products are on the market?
The Difluprednate drug market contains 6 NDCs from 6 manufacturers — 5 generic and 1 brand product.
What is the price range for Difluprednate?
NADAC reference prices for Difluprednate range from $9.6866 to $42.2491 per ML — the most expensive product costs about 4.4× the cheapest.
Is generic Difluprednate cheaper than brand?
The average generic NADAC for Difluprednate is $9.7065 per ML, versus $42.2491 for brand-labeled products — brand versions average about 4.4× the generic price.
Which manufacturers make Difluprednate?
6 manufacturers list Difluprednate in NADAC. Ranked by number of NDCs, the largest are Sandoz Inc. (1), Cipla USA Inc. (1), Mylan Pharmaceuticals Inc. (1), Upsher-Smith Laboratories LLC (1), Caplin Steriles Limited (1).
How has the price of Difluprednate changed recently?
Over the past 7 days, 4 Difluprednate NDCs rose and 0 fell, with a market-wide average change of +8.6%.