Difluprednate
6 NDCs across 6 manufacturers|5 Generic,1 Brand
▸ More about this market▾ Less
The brand product was first FDA-approved on Jun 23, 2008, and the first generic was approved Aug 9, 2021. FDA's Orange Book lists 9 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $15 million on Difluprednate across 134,000 claims for 62,000 beneficiaries.
Difluprednate is available as 6 NDCs from 6 manufacturers (5 generic, 1 brand), with NADAC prices from $8.92 to $42.25 per ML — the most expensive product costs about 4.7× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
6
5G / 1B
Manufacturers
6
competing in market
Price Spread
$8.92 – $42.25
per ML
7d Activity
avg +16.3% WoW · of 6 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Manufacturer Breakdown
6 manufacturers producing DIFLUPREDNATE(1 pricing outlier)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
DUREZOL 0.05% EYE DROPS | $42.2491 per ML | -0.11% |
DIFLUPREDNATE 0.05% EYE DROP | $9.7858 per ML | — |
DIFLUPREDNATE 0.05% EYE DROP | $8.9184 per ML | +20.43% |
DIFLUPREDNATE 0.05% EYE DROP | $8.9184 per ML | +20.43% |
DIFLUPREDNATE 0.05% EYE DROP | $8.9184 per ML | +20.43% |
DIFLUPREDNATE 0.05% EYE DROP | $8.9184 per ML | +20.43% |
Frequently Asked Questions
When did Difluprednate become available as a generic?
FDA approved the first generic Difluprednate (ANDA) on Aug 9, 2021. The Orange Book currently lists 9 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Difluprednate?
In 2024, Medicare Part D spent $15 million on Difluprednate across 134,000 claims for 62,000 beneficiaries.
How many Difluprednate products are on the market?
The Difluprednate drug market contains 6 NDCs from 6 manufacturers — 5 generic and 1 brand product.
What is the price range for Difluprednate?
NADAC reference prices for Difluprednate range from $8.9184 to $42.2491 per ML — the most expensive product costs about 4.7× the cheapest.
Is generic Difluprednate cheaper than brand?
The average generic NADAC for Difluprednate is $9.0919 per ML, versus $42.2491 for brand-labeled products — brand versions average about 4.6× the generic price.
Which manufacturers make Difluprednate?
6 manufacturers list Difluprednate in NADAC. Ranked by number of NDCs, the largest are Sandoz Inc. (1), Cipla USA Inc. (1), Mylan Pharmaceuticals Inc. (1), Upsher-Smith Laboratories LLC (1), Caplin Steriles Limited (1).
How has the price of Difluprednate changed recently?
Over the past 7 days, 4 Difluprednate NDCs rose and 1 fell, with a market-wide average change of +16.3%.