Product Information
LOTEPREDNOL ETABONATE 0.5% DRP is a generic product labeled by NorthStar Rx LLC, priced at $21.1990 per ML under NDC 72603032402. Its NADAC has been published 88 times since Jan 29, 2025.
FDA first approved this application on Feb 26, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
5 mg/mL
Manufacturer
NorthStar Rx LLCNDC
72603032402
Classification
Generic
Dosage Form
SUSPENSION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
LOTEPREDNOL ETABONATEApproval Type
Generic (ANDA)
FDA Application
ANDA212450FDA Approved
2/26/2021
TE Code
AB
On Market Since
9/1/2024
Pharmacological Classes
Price Statistics
The NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has been published 88 times since Jan 29, 2025, and over the history we have for it it has risen 2.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $21.1990 per ML |
|---|---|
| All-time high | $22.0153 (Aug 12, 2026) |
| All-time low | $8.9795 (Apr 23, 2025) |
| 52-week high | $22.0153 |
| 52-week low | $19.6396 |
| Median price | $20.2219 |
| Average price | $18.4804 |
| Largest weekly change | +32.0% (May 21, 2025) |
| Weeks tracked | 88 |
| Tracking since | Jan 29, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 51% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
NorthStar Rx LLC manufacturer profile
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Drug market
LOTEPREDNOL ETABONATE market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LOTEPREDNOL ETABONATE 0.5% DRP?
The current National Average Drug Acquisition Cost (NADAC) for LOTEPREDNOL ETABONATE 0.5% DRP, manufactured by NorthStar Rx LLC, is $21.1990 per ML (NDC 72603032402), effective Sep 30, 2026.
How has the price of LOTEPREDNOL ETABONATE 0.5% DRP changed over time?
Over the history we have for it, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has risen 2.2%. It has been tracked across 88 weekly CMS publications since Jan 29, 2025.
What are the highest and lowest recorded NADAC prices for LOTEPREDNOL ETABONATE 0.5% DRP?
Since Jan 29, 2025, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has ranged from a low of $8.9795 (Apr 23, 2025) to a high of $22.0153 (Aug 12, 2026), with a median of $20.2219 per ML.
Are there cheaper alternatives to LOTEPREDNOL ETABONATE 0.5% DRP?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, LOTEPREDNOL ETABONATE 0.5% DRP, is $10.4737 per ML — about 51% below LOTEPREDNOL ETABONATE 0.5% DRP.
Who manufactures LOTEPREDNOL ETABONATE 0.5% DRP?
LOTEPREDNOL ETABONATE 0.5% DRP (NDC 72603032402) is labeled by NorthStar Rx LLC, and CMS classifies it as a generic product.