Product Information
TRAMADOL HCL 25 MG TABLET is a generic product labeled by Advagen Pharma Ltd., priced at $3.3665 per EA under NDC 72888016230. Its NADAC has been published 116 times since Jul 17, 2024.
FDA first approved this application on Jun 28, 2019. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Advagen Pharma Ltd.NDC
72888016230
Classification
Generic
Dosage Form
TABLET, COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
TRAMADOL HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA208708FDA Approved
6/28/2019
TE Code
AB
On Market Since
11/28/2023
Pharmacological Classes
Price Statistics
The NADAC for TRAMADOL HCL 25 MG TABLET has been published 116 times since Jul 17, 2024, and over the history we have for it it has risen 35.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.3665 per EA |
|---|---|
| All-time high | $3.3840 (Feb 11, 2026) |
| All-time low | $2.4916 (Jul 17, 2024) |
| 52-week high | $3.3840 |
| 52-week low | $3.2158 |
| Median price | $3.1736 |
| Average price | $3.0978 |
| Largest weekly change | +7.1% (Sep 18, 2024) |
| Weeks tracked | 116 |
| Tracking since | Jul 17, 2024 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Tramadol Hydrochloride market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Advagen Pharma Ltd. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Tramadol Hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Opioid Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRAMADOL HCL 25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for TRAMADOL HCL 25 MG TABLET, manufactured by Advagen Pharma Ltd., is $3.3665 per EA (NDC 72888016230), effective Sep 30, 2026.
How has the price of TRAMADOL HCL 25 MG TABLET changed over time?
Over the history we have for it, the NADAC for TRAMADOL HCL 25 MG TABLET has risen 35.1%. It has been tracked across 116 weekly CMS publications since Jul 17, 2024.
What are the highest and lowest recorded NADAC prices for TRAMADOL HCL 25 MG TABLET?
Since Jul 17, 2024, the NADAC for TRAMADOL HCL 25 MG TABLET has ranged from a low of $2.4916 (Jul 17, 2024) to a high of $3.3840 (Feb 11, 2026), with a median of $3.1736 per EA.
Are there cheaper alternatives to TRAMADOL HCL 25 MG TABLET?
No other NADAC-published product currently shares the active ingredient and strength of TRAMADOL HCL 25 MG TABLET in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures TRAMADOL HCL 25 MG TABLET?
TRAMADOL HCL 25 MG TABLET (NDC 72888016230) is labeled by Advagen Pharma Ltd., and CMS classifies it as a generic product.