Product Information
SINEMET 25-100 MG TABLET is a brand product labeled by Organon LLC, priced at $1.4236 per EA under NDC 78206016801. Its NADAC has been published 92 times since May 22, 2024.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the carbidopa and levodopa market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25; 100 mg/1; mg/1
Manufacturer
Organon LLCNDC
78206016801
Classification
Brand
Dosage Form
TABLET
Route
ORAL
Effective Date
1/1/2026
Active Ingredients
CARBIDOPA; LEVODOPAApproval Type
New Drug (NDA)
FDA Application
NDA017555FDA Approved
Before 1982
TE Code
AB
On Market Since
6/1/2021
Pharmacological Classes
Price Statistics
The NADAC for SINEMET 25-100 MG TABLET has been published 92 times since May 22, 2024, and over the history we have for it it has risen 10.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.4236 per EA |
|---|---|
| All-time high | $1.4236 (Feb 18, 2026) |
| All-time low | $1.2907 (May 22, 2024) |
| 52-week high | $1.4236 |
| 52-week low | $1.3558 |
| Median price | $1.3560 |
| Average price | $1.3386 |
| Largest weekly change | +5.0% (Jan 1, 2025) |
| Weeks tracked | 92 |
| Tracking since | May 22, 2024 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+5.0%
3Y
N/A
5Y
N/A
All
+10.3%
Last surveyed Feb 18, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of SINEMET 25-100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for SINEMET 25-100 MG TABLET, manufactured by Organon LLC, is $1.4236 per EA (NDC 78206016801), effective Feb 18, 2026.
How has the price of SINEMET 25-100 MG TABLET changed over time?
Over the history we have for it, the NADAC for SINEMET 25-100 MG TABLET has risen 10.3%. It has been tracked across 92 weekly CMS publications since May 22, 2024.
What are the highest and lowest recorded NADAC prices for SINEMET 25-100 MG TABLET?
Since May 22, 2024, the NADAC for SINEMET 25-100 MG TABLET has ranged from a low of $1.2907 (May 22, 2024) to a high of $1.4236 (Feb 18, 2026), with a median of $1.3560 per EA.
Are there cheaper alternatives to SINEMET 25-100 MG TABLET?
Yes. 6 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CARBIDOPA-LEVODOPA 25-100 TAB, is $0.0724 per EA — about 95% below SINEMET 25-100 MG TABLET.
Who manufactures SINEMET 25-100 MG TABLET?
SINEMET 25-100 MG TABLET (NDC 78206016801) is labeled by Organon LLC, and CMS classifies it as a brand product.