Product Information

SINEMET 25-100 MG TABLET is a brand product labeled by Organon LLC, priced at $1.4236 per EA under NDC 78206016801. Its NADAC has been published 92 times since May 22, 2024.

FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

The High Outlier badge above means this manufacturer's average price in the carbidopa and levodopa market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.

SINEMET 25-100 MG TABLET

carbidopa and levodopa
$1.4236per EA
High Outlier

Strength

25; 100 mg/1; mg/1

Manufacturer

Organon LLC

NDC

78206016801

Classification

Brand

Dosage Form

TABLET

Route

ORAL

Effective Date

1/1/2026

Active Ingredients

CARBIDOPA; LEVODOPA

Approval Type

New Drug (NDA)

FDA Application

NDA017555

FDA Approved

Before 1982

TE Code

AB

On Market Since

6/1/2021

Pharmacological Classes

Amino Acids
Aromatic
Aromatic Amino Acid

Price Statistics

The NADAC for SINEMET 25-100 MG TABLET has been published 92 times since May 22, 2024, and over the history we have for it it has risen 10.3%. The table below summarizes its recorded NADAC range and movement.

Current price$1.4236 per EA
All-time high$1.4236 (Feb 18, 2026)
All-time low$1.2907 (May 22, 2024)
52-week high$1.4236
52-week low$1.3558
Median price$1.3560
Average price$1.3386
Largest weekly change+5.0% (Jan 1, 2025)
Weeks tracked92
Tracking sinceMay 22, 2024

Price History

1W

N/A

1M

N/A

3M

N/A

6M

N/A

1Y

+5.0%

3Y

N/A

5Y

N/A

All

+10.3%

Last surveyed Feb 18, 2026 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Frequently asked questions

What is the NADAC price of SINEMET 25-100 MG TABLET?

The current National Average Drug Acquisition Cost (NADAC) for SINEMET 25-100 MG TABLET, manufactured by Organon LLC, is $1.4236 per EA (NDC 78206016801), effective Feb 18, 2026.

How has the price of SINEMET 25-100 MG TABLET changed over time?

Over the history we have for it, the NADAC for SINEMET 25-100 MG TABLET has risen 10.3%. It has been tracked across 92 weekly CMS publications since May 22, 2024.

What are the highest and lowest recorded NADAC prices for SINEMET 25-100 MG TABLET?

Since May 22, 2024, the NADAC for SINEMET 25-100 MG TABLET has ranged from a low of $1.2907 (May 22, 2024) to a high of $1.4236 (Feb 18, 2026), with a median of $1.3560 per EA.

Are there cheaper alternatives to SINEMET 25-100 MG TABLET?

Yes. 6 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CARBIDOPA-LEVODOPA 25-100 TAB, is $0.0724 per EA — about 95% below SINEMET 25-100 MG TABLET.

Who manufactures SINEMET 25-100 MG TABLET?

SINEMET 25-100 MG TABLET (NDC 78206016801) is labeled by Organon LLC, and CMS classifies it as a brand product.