Product Information
SINEMET 25-100 MG TABLET is a brand product labeled by Organon LLC, priced at $1.4236 per EA under NDC 78206016801. Its NADAC has been published 92 times since May 22, 2024.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the carbidopa and levodopa market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25; 100 mg/1; mg/1
Manufacturer
Organon LLCNDC
78206016801
Classification
Brand
Dosage Form
TABLET
Route
ORAL
Effective Date
1/1/2026
Active Ingredients
CARBIDOPA; LEVODOPAApproval Type
New Drug (NDA)
FDA Application
NDA017555FDA Approved
Before 1982
TE Code
AB
On Market Since
6/1/2021
Pharmacological Classes
Price Statistics
The NADAC for SINEMET 25-100 MG TABLET has been published 92 times since May 22, 2024, and over the history we have for it it has risen 10.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.4236 per EA |
|---|---|
| All-time high | $1.4236 (Feb 18, 2026) |
| All-time low | $1.2907 (May 22, 2024) |
| 52-week high | $1.4236 |
| 52-week low | $1.3558 |
| Median price | $1.3560 |
| Average price | $1.3386 |
| Largest weekly change | +5.0% (Jan 1, 2025) |
| Weeks tracked | 92 |
| Tracking since | May 22, 2024 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+4.9%
3Y
N/A
5Y
N/A
All
+10.3%
Last surveyed Feb 18, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Organon LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
carbidopa and levodopa market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Aromatic Amino Acid class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of SINEMET 25-100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for SINEMET 25-100 MG TABLET, manufactured by Organon LLC, is $1.4236 per EA (NDC 78206016801), effective Feb 18, 2026.
How has the price of SINEMET 25-100 MG TABLET changed over time?
Over the history we have for it, the NADAC for SINEMET 25-100 MG TABLET has risen 10.3%. It has been tracked across 92 weekly CMS publications since May 22, 2024.
What are the highest and lowest recorded NADAC prices for SINEMET 25-100 MG TABLET?
Since May 22, 2024, the NADAC for SINEMET 25-100 MG TABLET has ranged from a low of $1.2907 (May 22, 2024) to a high of $1.4236 (Feb 18, 2026), with a median of $1.3560 per EA.
Are there cheaper alternatives to SINEMET 25-100 MG TABLET?
Yes. 6 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CARBIDOPA-LEVODOPA 25-100 TAB, is $0.0724 per EA — about 95% below SINEMET 25-100 MG TABLET.
Who manufactures SINEMET 25-100 MG TABLET?
SINEMET 25-100 MG TABLET (NDC 78206016801) is labeled by Organon LLC, and CMS classifies it as a brand product.